Effects of oral beraprost sodium, a prostaglandin I2 analogue, on endothelium dependent vasodilatation in the forearm of patients with coronary artery disease

Clinical and Experimental Pharmacology & Physiology
S OhataTetsuya Higami

Abstract

1. Previous clinical studies with prostaglandin I(2) (PGI(2)) analogue beraprost sodium suggested the potential effects on protection of cardiovascular events in patients with peripheral artery disease. Although the mechanism is not well known, experimental studies have shown protective effects of endothelial cells. This study was designed to examine the effects of beraprost sodium on vascular endothelial function in the forearm of patients with coronary artery disease. 2. Beraprost sodium (120 microg/day) was orally administered to 14 coronary artery disease patients for 4 weeks and then stopped for 4 weeks. Eleven control patients did not receive beraprost sodium treatment. Reactive hyperemia was induced in the forearm, endothelium-dependent vasodilatation was assessed by plethysmography, and urinary 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)) was measured at baseline, 4 weeks and 8 weeks. 3. Both groups had similar reactive hyperemic responses at baseline. In the control group, reactive hyperemic response and urinary 8-iso-PGF(2alpha) remained unchanged for 8 weeks. In the beraprost group, maximum forearm blood flow increased significantly (P = 0.01) after 4 weeks of treatment and returned to baseline at 8 weeks. Durat...Continue Reading

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Citations

Jan 7, 2010·Journal of Hypertension·Patrick Crosswhite, Zhongjie Sun
Feb 7, 2014·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Takayasu OhtakeShuzo Kobayashi
Jun 5, 2012·Journal of Atherosclerosis and Thrombosis·Mao TakahashiKohji Shirai
Sep 30, 2006·Chemistry : a European Journal·Leticia Jiménez-GonzálezIgnacio Rodríguez-García
Apr 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·San Bao ChaiChao Shu Tang

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