Effects of oral H1 and H2 receptor antagonists in asthma

British Journal of Clinical Pharmacology
J D LeopoldA P Smith


1 There is evidence that H2 receptors are present in the lung, both on bronchial smooth muscle and mast cells. In animal studies, stimulation of H2 receptors causes a diminution, and conversely H2 receptor blockade can increase, smooth muscle contraction and mediator release. 2 The effects of H2 receptor blockade in ten patients with asthma has been studied using oral cimetidine in a dose of 1 g daily for 1 week. Treatment was compared with placebo and the H1 receptor antagonist chlorpheniramine. 3 There was no alteration in the severity of naturally-occurring or exercise-induced asthma with cimetidine or chlorpheniramine. 4 H2 receptor blockade with oral cimetidine in conventional doses is without ill effect in asthma. The use of larger parenteral doses is discussed.


Jan 1, 1977·The Journal of Allergy and Clinical Immunology·V T Popa
Jan 1, 1975·International Archives of Allergy and Applied Immunology·L M Lichtenstein
Nov 1, 1977·The Journal of Allergy and Clinical Immunology·R A SimonE M Tan


Jan 1, 1985·European Journal of Clinical Pharmacology·F P MaesenJ P Rihoux
Sep 1, 1982·Klinische Wochenschrift·D Reinhardt, U Borchard
Jan 1, 1982·Pharmacology & Therapeutics·N M Eiser
Oct 8, 2003·The Journal of Allergy and Clinical Immunology·Harold S Nelson
Jan 4, 2008·Nature Reviews. Drug Discovery·R L ThurmondPaul J Dunford
Jul 1, 1983·British Journal of Diseases of the Chest·J White, N M Eiser
May 1, 1985·British Journal of Clinical Pharmacology·J M HughesD M Temple
Nov 1, 1982·The Journal of Allergy and Clinical Immunology·C D BrooksC Metzler
Apr 24, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A P KollmeierR L Thurmond
Nov 1, 1984·British Journal of Clinical Pharmacology·S G Nogrady, A G Hahn

Related Concepts

Double-Blind Method
Forced Expiratory Flow Rates
Antihistamines, Classical
Histamine H2 Antagonists
Peak Expiratory Flow Rate Measurement

Related Feeds


This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.