Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet

Lipids in Health and Disease
Qian ZhangQing Gu

Abstract

Supplementation with Selenium (Se) has been shown to lower blood cholesterol and increase tissue concentrations of the antioxidant glutathione (GSH); however, the effects of Se supplementation, in combination with supplemental magnesium, on high fat-induced hyperlipidemia have not been studied. This study was designed to elucidate the effects of oral selenium and magnesium co-supplementation on antihyperlipidemic and hepatoprotective, antioxidative activities, and related gene expression in a hyperlipidemic rat model. Forty male Sprague Dawley rats were divided into 4 groups: one group served as control group (CT), provided control diet; The other groups were made hyperlipidemic with high-fat diet; specifically, a high-fat diet group (HF); low-dose selenium (0.05 mg/kg·bw) + low-dose magnesium (5.83 mg/kg·bw) supplement high-fat diet group (HF + LSe + LMg) and high-dose selenium (0.10 mg/kg·bw) + high-dose magnesium (58.33 mg/kg·bw) supplement high-fat diet group (HF + HSe + HMg). The first 4 weeks of the experiment was a hyperlipidemia inducing period using high-fat diet and the following 8 weeks involved in selenium and magnesium co-supplementation. On day 0, 20, 40 and 60 of the intervention, lipid profile was measured. At t...Continue Reading

References

Aug 29, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sanjiv Dhingra, Mohinder P Bansal
Mar 12, 2010·Critical Reviews in Biochemistry and Molecular Biology·Maggie S Strable, James M Ntambi
Feb 3, 2011·European Journal of Pharmacology·Jun-Ho ChoiSun-Mee Lee
Jan 6, 2012·The American Journal of Clinical Nutrition·Yiqing Song, Simin Liu
Feb 23, 2012·Current Topics in Medicinal Chemistry·Isela GarcíaGenerosa Gómez
Jun 2, 2012·World Journal of Gastroenterology : WJG·Yoshihisa TakahashiToshio Fukusato
Sep 30, 2014·Archives of Gerontology and Geriatrics·Chen ChenSujuan Gao
Aug 12, 2016·Molecular Medicine Reports·Chae-Yun KimHyo-Jin An
Feb 19, 2017·International Journal of Biological Macromolecules·Maheen Mahwish SurhioMing Ye
Mar 10, 2018·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Małgorzata KiełczykowskaIrena Musik

❮ Previous
Next ❯

Citations

Jul 11, 2019·Journal of Medicinal Food·Vanessa Azevedo de JesuzAnderson Junger Teodoro
Sep 8, 2019·Hormones : International Journal of Endocrinology and Metabolism·Stergios A PolyzosLeonidas Duntas
Sep 13, 2020·International Journal of Environmental Research and Public Health·Gema BarrientosMarcos Maynar
Mar 23, 2021·Journal of Dietary Supplements·Patricia Ferrante DraghiFernando Luiz Affonso Fonseca
Apr 28, 2021·Journal of Agricultural and Food Chemistry·Meng ZhaoLin Lei

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA

Software Mentioned

GraphPad
Graphpad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.