PMID: 9176043Apr 1, 1997Paper

Effects of ordinary meals on plasma concentrations of 3,4-dihydroxyphenylalanine, dopamine sulphate and 3,4-dihydroxyphenylacetic acid

Clinical Science
E EldrupN J Christensen

Abstract

1. Plasma concentrations of 3,4-dihydroxyphenylalanine (DOPA), dopamine sulphate (DA-S), and 3,4-dihydroxyphenylacetic acid (DOPAC) in humans have been claimed to be indexes of sympathetic nervous activity, but the source and significance of plasma DOPA, DOPAC and DA-S have not been completely elucidated. 2. The effects of ordinary meals on plasma concentrations of total dopamine, mainly DA-S, DOPAC and DOPA were studied in seven healthy subjects. Venous blood was collected every hour for 25 h, while subjects were either fasting or received three meals at 9.00 hours, 13.00 hours and 18.00 hours. Catecholamines and metabolites were determined by reverse-phase HPLC with electrochemical detection. Neutral amino acids were measured by ion-exchange chromatography with photometric detection. 3. The food contained relatively little DOPA as compared with phenylalanine, tyrosine, isoleucine and tryptophan. The content of DA and DA-S varied considerably, with the greatest amount in the evening meal of open sandwiches. 4. Plasma DOPA decreased significantly after the meals at 13.00 hours and 18.00 hours, whereas concentrations of the other amino acids increased as expected. 5. Plasma DA-S increased significantly after meals and especially...Continue Reading

Citations

Jul 2, 2009·The Journal of Clinical Endocrinology and Metabolism·Wilhelmina H A de JongIdo P Kema
Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·D S GoldsteinG Eisenhofer
Aug 20, 2004·Pharmacological Reviews·Graeme EisenhoferDavid S Goldstein
Jan 11, 2019·Molecular Psychiatry·Zachary J FarinoZachary Freyberg
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·E Eldrup, E A Richter
Nov 11, 2009·Molecular Endocrinology·Zhi-Liang ChuJames Leonard
May 12, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·S M Matt, P J Gaskill
Jun 19, 2019·Journal of Immunoassay & Immunochemistry·Sulaiman Amur Said Al AlwiNurudeen Hassan
Feb 17, 2021·Translational Psychiatry·Despoina AslanoglouZachary Freyberg

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