Effects of organic chemicals derived from ambient particulate matter on lung inflammation related to lipopolysaccharide

Archives of Toxicology
Ken-ichiro InoueToshikazu Yoshikawa

Abstract

The effects of components of ambient particulate matter (PM) on individuals with predisposing respiratory disorders are not well defined. We have previously demonstrated that airway exposure to diesel exhaust particles (DEP) or organic chemicals (OC) extracted from DEP (DEP-OC) enhances lung inflammation related to bacterial endotoxin (lipopolysaccharide, LPS). The present study aimed to examine the effects of airway exposure to OC extracted from urban PM (PM-OC) on lung inflammation related to LPS. ICR mice were divided into four experimental groups that intratracheally received vehicle, LPS (2.5 mg/kg), PM-OC (4 mg/kg), or PM-OC + LPS. Lung inflammation, lung water content, and lung expression of cytokines were evaluated 24 h after intratracheal administration. LPS challenge elicited lung inflammation evidenced by cellular profiles of bronchoalveolar lavage fluid and lung histology, which was further aggravated by the combined challenge with PM-OC. The combination with PM-OC and LPS did not significantly exaggerate LPS-elicited pulmonary edema. LPS instillation induced elevated lung expression of interleukin-1beta, macrophage inflammatory protein-1alpha, macrophage chemoattractant protein-1, and keratinocyte chemoattractant, ...Continue Reading

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Citations

Aug 9, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Staci D BilboJaclyn M Schwarz
Mar 3, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ken-ichiro Inoue, Hirohisa Takano
Feb 22, 2008·Neurotoxicology·Sheba M J MohanKumarBellina Veronesi
Feb 11, 2010·Journal of Environmental Monitoring : JEM·D TraversiG Gilli
Dec 19, 2012·Journal of Occupational and Environmental Medicine·Lina MadaniyaziXiaochuan Pan
Apr 10, 2019·Annals of Biomedical Engineering·Brittany N J DavisGeorge A Truskey

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