Abstract
Polychlorinated biphenyl congeners that are abundant in environmental samples, and known to induce hepatic monooxygenase isozymes in the P450IA gene subfamily in mammals, were examined for their ability to induce hepatic monooxygenase activity in scup, a marine teleost. Scup were dosed ip with 3,3',4,4'-tetrachlorobiphenyl (congener 77), 2,3,3',4,4'-pentachlorobiphenyl (congener 105), 2,3',4,4',5-pentachlorobiphenyl (congener 118), 2,2',3,4,4',5'-hexachlorobiphenyl (congener 138), 2,2',3,3',4,4'-hexachlorobiphenyl (congener 128), or beta-naphthoflavone and examined for increases in ethoxyresorufin O-deethylase (EROD) activity, immunodetectable cytochrome P450E (the EROD catalyst in scup), and in vitro translatable mRNA for P450E. Monooxygenase parameters were significantly induced only by 3,3',4,4'-tetrachlorobiphenyl (TCB). However, while translatable mRNA for P450E was induced at all doses (1, 5, and 10 mg/kg), EROD activity and P450E were decreased at the 5 and 10 mg/kg doses, relative to the response at 1 mg/kg. A strong relationship between residual TCB concentration in the liver and the decreased EROD activity was evident at the higher doses of TCB. Aminopyrine N-demethylase, a monooxygenase activity not catalyzed by P450...Continue Reading
References
Dec 1, 1979·Biochemical Pharmacology·J J StegemanA Orren
Jun 30, 1979·Toxicology and Applied Pharmacology·R F AddisonD C Darrow
May 31, 1979·Annals of the New York Academy of Sciences·C R ElcombeJ J Lech
Nov 27, 1979·Biochemistry·J M ChirgwinW J Rutter
Aug 1, 1976·Acta Pharmacologica Et Toxicologica·U LidmanG Axelson
Sep 1, 1986·Archives of Biochemistry and Biophysics·S S ParkH V Gelboin
Aug 1, 1987·Toxicology and Applied Pharmacology·R Voorman, S D Aust
Feb 1, 1989·Archives of Biochemistry and Biophysics·P J Kloepper-Sams, J J Stegeman
Jan 1, 1988·The Science of the Total Environment·K C Jones
Mar 1, 1988·Analytical Chemistry·J C DuinkerG Petrick
Jul 1, 1988·DNA·L J HeilmannD W Nebert
Apr 1, 1987·Environmental Health Perspectives·K M KleinowJ J Lech
Apr 1, 1987·Environmental Health Perspectives·J J Stegeman, P J Kloepper-Sams
Feb 15, 1987·Archives of Biochemistry and Biophysics·P J Kloepper-SamsJ J Stegeman
May 1, 1987·General and Comparative Endocrinology·E A Snowberger, J J Stegeman
Jan 1, 1985·Journal of Toxicology and Environmental Health·B LeeceS Safe
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Jan 1, 1984·Critical Reviews in Toxicology·S Safe
Jan 1, 1981·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·M J MelanconJ J Lech
Aug 1, 1981·Chemico-biological Interactions·M O James, P J Little
Sep 15, 1983·Toxicology and Applied Pharmacology·J AndresS Safe
Oct 15, 1983·Archives of Biochemistry and Biophysics·A V KlotzC Walsh
Sep 30, 1983·Toxicology and Applied Pharmacology·T Shimada, Y Sawabe
Jul 1, 1984·Analytical Biochemistry·A V KlotzC Walsh
Mar 1, 1980·Chemico-biological Interactions·A ParkinsonS Safe
Dec 22, 1981·Biochemistry·L S KaminskyF P Guengerich
Apr 1, 1982·Chemico-biological Interactions·S BandieraA B Okey
Sep 1, 1982·Toxicology Letters·T Sawyer, S Safe
Mar 15, 1980·Biochemical Pharmacology·R L Binder, J J Stegeman
Oct 1, 1953·The Biochemical Journal·T NASH
Mar 14, 1986·Science·J J StegemanJ W Farrington
Citations
Jun 26, 2008·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·David Hernández-MorenoMarcos Pérez-López
May 8, 2001·Environmental Toxicology·J R PetrulisN J Bunce
Oct 12, 2001·Environmental Toxicology· Tugiyono, M M Gagnon
Apr 25, 2000·Biochemical and Biophysical Research Communications·H Iwata, J J Stegeman
Apr 1, 1991·Archives of Environmental Contamination and Toxicology·J U SkaareE Egaas
Jun 1, 1991·Fish Physiology and Biochemistry·M Celander, L Förlin
Jul 1, 1995·Environmental Science and Pollution Research International·M TysklindM van den Berg
Jul 16, 2009·Ecotoxicology·Pedro M CostaMaria H Costa
May 7, 2009·Environmental Monitoring and Assessment·Alaattin SenIsmet Cok
Apr 28, 2010·Environmental Monitoring and Assessment·Sandro FroehnerKarina Scurupa Machado
Nov 26, 2010·Environmental Monitoring and Assessment·Lílian NogueiraEduardo Alves de Almeida
Jan 19, 2012·Fish Physiology and Biochemistry·Eric D H DurieuxDavid J Ostrach
Jul 15, 1990·Biochemical Pharmacology·C L MirandaD R Buhler
Jan 1, 1995·Chemosphere·D B O'HareR Gill
Jun 1, 1996·Chemosphere·H M Sleiderink, J P Boon
Mar 1, 1991·The Science of the Total Environment·J M EveraartsJ P Boon
Apr 1, 1992·The Science of the Total Environment·J P BoonA Goksøyr
Feb 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N TakahashiD E Williams
Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·K M KleinowJ J Lech
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A GoksøyrA M Husøy
Feb 7, 1997·Biochemical Pharmacology·A LorenzenM E Hahn
Apr 4, 1997·Biochemical Pharmacology·R D WhiteJ J Stegeman
Jul 22, 1998·Mutation Research·D E WilliamsD R Buhler
Jul 22, 1998·Mutation Research·I Wirgin, J R Waldman
Sep 27, 2001·Chemosphere·V P PalaceW L Lockhart
Jun 7, 2002·The Science of the Total Environment·Mark E Hahn
May 10, 2000·The Science of the Total Environment·C Sarasquete, H Segner
Apr 23, 2003·Ecotoxicology and Environmental Safety·V L MariaM A Santos
May 9, 2001·Environment International·M Pacheco, M A Santos
Nov 1, 2003·Environment International·V L MariaM A Santos
Sep 1, 2000·Aquatic Toxicology·J J Schlezinger, J J Stegeman
Feb 13, 2001·Aquatic Toxicology·J J Schlezinger, J J Stegeman
Mar 20, 2001·Aquatic Toxicology·J Y WilsonR F Addison
Jul 14, 2001·Aquatic Toxicology·D L VilleneuveJ P Giesy
Jun 29, 2002·Aquatic Toxicology·John P GiesyLisa L Williams
Sep 3, 2002·Aquatic Toxicology·Shannon Mala BardJohn J Stegeman
Jul 11, 1998·Biochimica Et Biophysica Acta·A YawetzJ J Stegeman
Jun 4, 1999·Toxicology Letters·J R Petrulis, N J Bunce
Jul 1, 1997·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·D M OttoT W Moon
Feb 19, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·S L Levine, J T Oris
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M E HahnD E Tillitt
Jan 16, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·J J SchlezingerJ J Stegeman
Aug 1, 2002·Environmental Toxicology and Pharmacology·Lene Ostby, Ase Krøkje
Jan 18, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·S A M Al-Arabi, A Goksøyr
Jul 27, 2000·Food Additives and Contaminants·M van den BergD Schrenk
Aug 1, 1991·Journal of Toxicology and Environmental Health·M J Mac, C C Edsall
Apr 23, 2005·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Arthur ChiuShawn Gerstenberger
Feb 27, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·S M BelloM E Hahn
Oct 1, 1995·Pharmacology & Toxicology·D M Otto, T W Moon
Jul 1, 1996·Environmental Health Perspectives·S A VillalobosP Kelly