Effects of orthotopic cardiac transplantation on structural microangiopathy and abnormal hemodynamics in idiopathic dilated cardiomyopathy

The American Journal of Cardiology
H WroblewskiJ Kastrup

Abstract

To examine whether cardiac transplantation would reverse morphologic and hemodynamic changes in peripheral circulation in idiopathic dilated cardiomyopathy, the structure of terminal arterioles and minimal vascular resistance were measured in skin at the dorsum of the foot in the same 14 patients before and 80 +/- 21 (mean +/- SD) days and 387 +/- 46 days after transplantation. The results were compared with data from a group of 16 healthy subjects. Blood flow was measured by the local technetium-99m pertechnetate washout method in a vascular bed relaxed with histamine. Structural microangiopathy (enhanced thickening of the basement membranes) in the arterioles was disclosed in skin biopsies in 11 of 14 patients before transplant, but in none of the 16 control subjects (p < 0.002). These abnormalities were unchanged 80 days after cardiac transplantation. However, arteriolar wall thickening was significantly reduced over the 1-year period after transplantation (p < 0.05), but this was not complete. Transplantation also led to a significant delayed decrease in minimal vascular resistance: before transplantation, 10.1 +/- 3.2 mm Hg.ml-1.100 g.min (mean +/- SD); 80 days after transplantation, 9.3 +/- 3.1 mm Hg.ml-1.100 g.min (p = N...Continue Reading

References

Sep 1, 1987·Scandinavian Journal of Clinical and Laboratory Investigation·J KastrupN A Lassen
May 1, 1988·The American Journal of Cardiology·L I SinowayR Zelis
Sep 1, 1981·American Heart Journal·J N CohnS Goldsmith
Jun 1, 1983·Journal of the American College of Cardiology·S R GoldsmithJ N Cohn

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