Effects of osteoarthritis and pathological walking on contact stresses in femoral cartilage

Biomechanics and Modeling in Mechanobiology
J MabumaW Ehlers

Abstract

Osteoarthritis is a widespread abnormality in synovial joints leading to increasing pain and potential work disability in middle-aged and older populations. A primary cause of osteoarthritis is related to damages from high local stresses combined with insufficient self-healing of cartilage. In this framework, it is the goal of the present contribution to offer a thermodynamically consistent simulation of a highly anisotropic, heterogeneous, osmotic swelling and poroviscoelastic model of healthy and osteoarthritic articular cartilage based on the Theory of Porous Media. Physiological and pathological loading patterns are included by means of multi-body system calculations on patients. The contact stresses at the cartilage surface are represented by means of three-dimensional and simplified stereographic views of the femoral head. For normal walking, the stress peaks are higher in the degenerated case than in the healthy case. Interestingly, pathological walking combined with degenerated cartilage tissue minimises the occurrence of high local stresses.

References

Aug 1, 1991·Journal of Biomechanical Engineering·W M LaiV C Mow
Jan 1, 1988·Journal of Biomechanics·G BergmannA Rohlmann
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W A HodgeR W Mann
Sep 1, 1972·Journal of Biomechanics·W C HayesL F Mockros
Jan 1, 1983·Journal of Biomechanics·T D Brown, D T Shaw
Feb 1, 1980·Journal of Biomechanical Engineering·V C MowC G Armstrong
Jan 1, 1993·Archives of Orthopaedic and Trauma Surgery·A IglicF Srakar
Jul 23, 1999·Clinical Orthopaedics and Related Research·J A HippS B Murphy
May 19, 2000·Medical Engineering & Physics·J Z WuM Epstein
Feb 22, 2001·Journal of Biomechanics·J RasmussenM Voigt
Jun 19, 2001·Journal of Biomechanics·G BergmannG N Duda
Apr 6, 2002·Journal of Biomechanics·Ge WuUNKNOWN Standardization and Terminology Committee of the International Society of Biomechanics
Sep 5, 2003·Osteoarthritis and Cartilage·S SaarakkalaJ Töyräs
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Jul 14, 2005·Journal of Anatomy·Matej DanielVeronika Kralj-Iglic
May 20, 2006·Biomechanics and Modeling in Mechanobiology·W WilsonC C van Donkelaar
Nov 1, 2006·NMR in Biomedicine·Wilfried Gründer
Jun 1, 2007·Journal of Biomechanical Engineering·Zohar YosibashCharles Milgrom
Oct 17, 2007·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·M CiavarellaM Giacopini
Jul 29, 2008·Biomechanics and Modeling in Mechanobiology·W EhlersB Markert
Jun 26, 2009·Magnetic Resonance Imaging·Takashi AzumaSadami Tsutsumi
Apr 12, 2011·IEEE Transactions on Medical Imaging·Magnus B LilledahlCatharina de Lange Davies
Jul 5, 2011·Journal of Biomechanics·Mateusz Maria JuszczykMarco Viceconti
Mar 5, 2013·Journal of Biomechanics·Christine L AbrahamAndrew E Anderson

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