Effects of osteochondral defect size on cartilage regeneration using a double-network hydrogel

BMC Musculoskeletal Disorders
Kotaro HigaKazunori Yasuda

Abstract

There has been increased interest in one-step cell-free procedures to avoid the problems related to cell manipulation and its inherent disadvantages. We have studied the chondrogenic induction ability of a PAMPS/PDMAAm double-network (DN) gel and found it to induce chondrogenesis in animal osteochondral defect models. The purpose of this study was to investigate whether the healing process and the degree of cartilage regeneration induced by the cell-free method using DN gel are influenced by the size of osteochondral defects. A total of 63 mature female Japanese white rabbits were used in this study, randomly divided into 3 groups of 21 rabbits each. A 2.5-mm diameter osteochondral defect was created in the femoral trochlea of the patellofemoral joint of bilateral knees in Group I, a 4.3-mm osteochondral defect in Group II, and a 5.8-mm osteochondral defect in Group III. In the right knee of each animal, a DN gel plug was implanted so that a vacant space of 2-mm depth was left above the plug. In the left knee, we did not conduct any treatment to obtain control data. Animals were sacrificed at 2, 4, and 12 weeks after surgery, and gross and histological evaluations were made. The present study demonstrated that all sizes of the ...Continue Reading

References

Apr 1, 1993·The Journal of Bone and Joint Surgery. American Volume·F ShapiroM J Glimcher
Aug 15, 1998·Arthritis and Rheumatism·J A Buckwalter, H J Mankin
Dec 16, 1998·The American Journal of Sports Medicine·B R MandelbaumL Peterson
May 20, 2000·Clinical Orthopaedics and Related Research·L PetersonA Lindahl
Feb 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·I M Driesang, E B Hunziker
Apr 23, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P AngeleB Johnstone
Jan 18, 2006·Tissue Engineering·Maarit HeinonenKatrina Nordström
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Nov 23, 2006·Journal of Biomedical Materials Research. Part a·Chinatsu AzumaYoshihito Osada
Aug 19, 2007·Osteoarthritis and Cartilage·M L Davies-TuckF M Cicuttini
Oct 5, 2007·Journal of Materials Science. Materials in Medicine·Yoshie TanabeYoshihito Osada
Apr 4, 2014·Bone & Joint Research·J L CookJ P Stannard
Jul 10, 2014·Current Stem Cell Research & Therapy·Vuk SavkovicJan-Christoph Simon
Feb 11, 2015·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Iain R MurrayBert R Mandelbaum
Jul 14, 2016·Journal of Tissue Engineering and Regenerative Medicine·Oliver F W GardnerMartin J Stoddart

❮ Previous
Next ❯

Citations

Jan 10, 2018·Advanced Healthcare Materials·Daniel A FoytEileen Gentleman
Nov 2, 2018·Archives of Orthopaedic and Trauma Surgery·Sebastian G WalterFrank A Schildberg
Jul 28, 2020·Frontiers in Bioengineering and Biotechnology·Bingchuan LiuXiaozhong Qu

❮ Previous
Next ❯

Software Mentioned

ICRS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.