Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs

BMC Musculoskeletal Disorders
Xia ChenYongde Peng

Abstract

Significant amount of bone mass is lost during the process of aging due to an imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption in bone marrow microenvironment, which leads to net bone loss in the aging population, resulting in the pathogenesis of osteoporosis. Firstly, differences in proliferative capacity of adipocyte or adipogenic differentiation in mouse mesenchymal stem cells (MMSCs) and senile mouse model-derived bone marrow mesenchymal stem cells (SMMSCs), as well as mRNA expression of OGN and PPARγ2 were observed. Secondly, osteogenic abilities of MMSCs and SMMSCs treated with rosiglitazone (a PPARγ2 agonist) to induce osteogenic changes were observed, and negative correlation of PPARγ2 with OGN was evaluated. Thirdly, the role of SMMSCs in promoting osteogenesis was examined through enhancing expression of OGN; besides, the related mechanism was investigated by means of expression of related adipocyte and osteoblast specific genes. Forced OGN expression by OGN-infected lentivirus could increase expression of Wnt5b, RUNX2, OCN, ALP and Colla1, as well as bone formation, while decreases expression of adipogenesis marker PPARγ2. It resulted in expression inhibition of adipocyte g...Continue Reading

References

Oct 1, 1995·Current Opinion in Genetics & Development·P TontonozB M Spiegelman
Aug 21, 2002·The Journal of Biological Chemistry·Adriana ZambottiPatricia Ducy
May 16, 2003·Nature·Gerard Karsenty
Jun 28, 2005·Journal of Bone and Mineral Metabolism·Hiroshi KawaguchiKozo Nakamura
Feb 24, 2011·Molecular & Cellular Proteomics : MCP·C Y X'avia ChanK W Michael Siu
Feb 22, 2012·The Journal of Biological Chemistry·Ken-ichiro TanakaHiroshi Kaji
Jan 31, 2013·World Journal of Orthopedics·Antonio HerreraLuis Gracia
Feb 19, 2013·Stem Cell Research & Therapy·Laura KyllönenSusanna Miettinen
Feb 26, 2014·BMC Complementary and Alternative Medicine·Feng YangZheng-Mao Lu
Apr 8, 2014·Journal of Bone Metabolism·Hiroshi Kaji
Apr 29, 2014·Journal of Women's Health·Juliana M KlingNicole P Sandhu
May 13, 2014·Maturitas·Stavros C Manolagas
Jan 23, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Cheng WangYu Wang

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Citations

Aug 10, 2019·Current Osteoporosis Reports·Jakob Starup-LindeAase Handberg
Mar 27, 2021·Molecular Genetics and Genomics : MGG·Boyin JiaHengxing Ba
Apr 4, 2021·International Journal of Molecular Sciences·Ramsha ShamsNarendra L Banik

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Methods Mentioned

BETA
light microscopy
PCR
flow cytometry

Software Mentioned

Prism
GraphPad

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