Effects of osteoprotegerin/TNFRSF11B in two models of abdominal aortic aneurysms

Molecular Medicine Reports
Emina VorkapicDick Wågsäter

Abstract

Osteoprotegerin (OPG), additionally termed tumor necrosis factor receptor superfamily member 11B, is produced by vascular smooth muscle cells (VSMCs) and endothelial cells in the vasculature, and its release may be modulated by pro‑inflammatory cytokines, including interleukin‑1β and tumor necrosis factor‑α. The present study investigated the effects of treatment with low‑dose human recombinant OPG on abdominal aortic aneurysm (AAA) development in mice. Mice were treated with 1 µg human recombinant OPG four times (or vehicle) for 2 weeks prior to inducing AAA. A total of two different models for inducing AAA were used to investigate the hypothesis as to whether OPG is involved in key events of AAA development, using osmotic mini‑pumps with angiotensin II in apolipoprotein‑E (ApoE‑/‑) mice for 28 days or using periaortic application of CaCl2 on the aorta in C57Bl/6J mice for 14 days. OPG was continuously administered during the experimental period. Histological staining using Masson's trichrome, Verhoeff's van‑Gieson and picro‑sirius red, in addition to reverse transcription‑quantitative polymerase chain reaction analysis of various markers, were used to analyze phenotypic alterations. Treatment with OPG had no inhibitory effect...Continue Reading

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Citations

Dec 15, 2019·Orthodontics & Craniofacial Research·Laís Cristina GiacobboPaula Cristina Trevilatto

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Methods Mentioned

BETA
biopsies
transgenic
PCR
ELISA

Software Mentioned

LeicaQWin
GraphPad Prism
SPSS

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