Effects of ovariohysterectomy on canine blood neutrophil respiratory burst: a chemiluminescence study

Veterinary Surgery : VS
Misse A M VäisänenOuti M Vainio

Abstract

To examine blood neutrophil counts and luminol-enhanced chemiluminescence (CL) responses in dogs undergoing ovariohysterectomy (OH), premedicated with 2 different drugs. Randomized clinical study. Forty-two healthy client-owned bitches. Dogs had OH under isoflurane anesthesia with either acepromazine or medetomidine, both in combination with butorphanol, administered as preanesthetic medication. Blood samples were collected when the dog was admitted, at the end of surgery, and the next day (approximately 20 hours after surgery). Blood neutrophils were counted automatically, and neutrophil oxidative activity was assessed by measuring blood CL responses (induced by opsonized zymosan and enhanced by luminol) at 37 degrees C for 40 minutes. Number of circulating neutrophils was significantly increased the day after surgery reflected by enhanced blood CL responses. Neutrophil CL, however, was not significantly altered. No significant differences were detected for perioperative Polymorphonuclear neutrophil (PMN) characteristics between the 2 preanesthetic regimens. In conclusion, despite clearly increasing the number of circulating neutrophils, OH did not significantly affect neutrophil respiratory burst, as measured by whole-blood C...Continue Reading

Associated Clinical Trials

Dec 4, 2019·mehmet ozsurmeli

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Citations

Jun 25, 2015·Acta Veterinaria Scandinavica·Rodrigo S HortaRoberto B Araújo

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