Effects of over-expressing resistin on glucose and lipid metabolism in mice

Journal of Zhejiang University. Science. B
You LiuShao-hong Chen

Abstract

Resistin, a newly discovered peptide hormone mainly secreted by adipose tissues, is present at high levels in serum of obese mice and may be a potential link between obesity and insulin resistance in rodents. However, some studies of rat and mouse models have associated insulin resistance and obesity with decreased resistin expression. In humans, no relationship between resistin level and insulin resistance or adiposity was observed. This suggests that additional studies are necessary to determine the specific role of resistin in the regulation of energy metabolism and adipogenesis. In the present study, we investigated the effect of resistin in vivo on glucose and lipid metabolism by over-expressing resistin in mice by intramuscular injection of a recombinant eukaryotic expression vector pcDNA3.1-Retn encoding porcine resistin gene. After injection, serum resistin and serum glucose (GLU) levels were significantly increased in the pcDNA3.1-Retn-treated mice; there was an obvious difference in total cholesterol (TC) level between the experiment and the control groups on Day 30. In pcDNA3.1-Retn-treated mice, both free fatty acid (FFA) and high density lipoprotein (HDL) cholesterol levels were markedly lower than those of control...Continue Reading

References

Nov 11, 1999·Current Opinion in Lipidology·D J Betteridge
Apr 15, 2000·Nature·J M Friedman
Feb 24, 2001·Nature·C M SteppanM A Lazar
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·C M SteppanM A Lazar
Mar 30, 2001·The Journal of Biological Chemistry·K H KimH S Sul
Dec 26, 2001·Trends in Endocrinology and Metabolism : TEM·Claire M Steppan, Mitchell A Lazar
Jan 1, 2003·Biochemical and Biophysical Research Communications·John N FainM Lloyd Hiler
Jan 18, 2003·The Journal of Clinical Investigation·Michael W RajalaLuciano Rossetti
Jun 13, 2003·Nature·Toshimasa YamauchiTakashi Kadowaki
Aug 29, 2003·The Journal of Biological Chemistry·Michal PravenecTheodore W Kurtz
Feb 21, 2004·Science·Ronadip R BanerjeeMitchell A Lazar
Jun 12, 2004·European Journal of Endocrinology·Haixia GongRonghua Chen
Jun 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Stephen E BorstGregory J Bagby
Jul 16, 2004·The Journal of Clinical Investigation·Hiroaki SatohJerrold M Olefsky
Oct 9, 2004·Endocrinology·Naoichi SatoHajime Nawata
Feb 3, 2005·Molecular and Cellular Biology·Claire M SteppanMitchell A Lazar
Jul 19, 2005·Domestic Animal Endocrinology·M H DaiZ Q Yang
Sep 3, 2005·FEBS Letters·Rengasamy Palanivel, Gary Sweeney
Oct 20, 2006·Molecular and Cellular Endocrinology·Andreas NiederwangerMichael T Pedrini

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Citations

May 24, 2011·Journal of Obesity·Anis AmirhakimiGholamhosein Amirhakimi
Jul 14, 2010·Tropical Medicine & International Health : TM & IH·Anthony D HarriesSydney Rosen
Aug 9, 2020·Immunopharmacology and Immunotoxicology·Ramachandran Vidhya, Carani Venkatraman Anuradha
Sep 21, 2018·Journal of Cardiovascular Translational Research·Ying CaiSui-Xin Liu

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