PMID: 8956375Nov 1, 1996Paper

Effects of oxazepam and lorazepam on implicit and explicit memory: evidence for possible influences of time course

Psychopharmacology
S H StewartM D Teehan

Abstract

The effects of oxazepam (30 mg), lorazepam (2 mg), and placebo on implicit and explicit memory were studied in two testing cycles, 100 and 170 min after drug administration. Thirty healthy volunteers were randomly assigned to one of three groups (placebo, oxazepam, or lorazepam) in a double-blind, independent groups design. Drug groups were equivalent prior to drug administration on a variety of cognitive measures. Following drug administration, both oxazepam and lorazepam equally impaired performance on a cued-recall explicit memory task relative to placebo, at both testing cycles. Relative to placebo, lorazepam markedly impaired priming on a word-stem completion implicit memory task, at both testing cycles. Consistent with previous work, oxazepam failed to produce impairments in priming on the word-stem completion task at 100 min post-drug administration. However, oxazepam was found significantly to impair priming on this latter task relative to placebo, at close to theoretical peak plasma concentration (i.e., 170 min post-drug administration). Explanations for the observed detrimental effect of oxazepam on implicit memory task performance are considered, including: possible time-dependent effects related to the relative rate...Continue Reading

Citations

Nov 5, 1998·Addictive Behaviors·S H StewartM Dongier
Mar 17, 1999·Brain Research. Cognitive Brain Research·E HirshmanJ Arndt
Feb 10, 2000·Brain Research. Cognitive Brain Research·T H RammsayerD Groh
Jan 22, 2003·British Journal of Clinical Pharmacology·S J de VisserJ M A van Gerven
Aug 19, 2007·CNS Drugs·Giulio PerugiCristina Toni
Feb 9, 2010·Pharmacology & Therapeutics·Anne GierschPierre Vidailhet
Mar 6, 2008·Human Psychopharmacology·S PompéiaO F A Bueno
Dec 31, 2002·Journal of Psychopharmacology·Allison MatthewsFrances Martin
Mar 5, 1999·Journal of Psychopharmacology·S E Buffett-JerrottM D Teehan
Apr 30, 1999·Journal of Psychopharmacology·M Z Mintzer, R R Griffiths
Apr 12, 2003·Journal of Psychopharmacology·S PompéiaO F A Bueno
Dec 5, 2013·Psychiatry Investigation·Hong-Seock LeeYun-Kyeung Choi

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