Effects of oxidative stress on immunosuppression induced by selenium deficiency in chickens

Biological Trace Element Research
Zi-Wei ZhangShi-Wen Xu

Abstract

Selenium (Se) is an important nutritional trace element possessing immune-stimulatory properties. The aim of this 75-day study was to investigate effect of oxidative stress on immunosuppression induced by selenium deficiency by determining antioxidative function, morphological changes, DNA damage, and immune function in immune organ of chickens. One hundred sixty 1-day-old chickens (egg-type birds) were randomly assigned to two groups of 80 each and were fed on a low-Se diet (0.032 mg/kg Se) or a control diet (0.282 mg/kg Se, sodium selenite), respectively. Se contents in blood and immune organ (thymus, spleen, bursa of Fabricius) were determined on days 30, 45, 60, and 75, respectively. Antioxidative function was examined by total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and xanthine oxidase (XOD), and oxidative damage was examined by malondialdehyde (MDA) detection. DNA damage was measured by comet assay, and immune function was examined by determining serum interleukin-1β (IL-1β), interleukin-2 (IL-2), and tumor necrosis factor (TNF) contents. The results showed that Se concentrations in the low-Se group were significantly lower (P < 0.05) than in the control group. Low-Se di...Continue Reading

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Citations

May 14, 2014·Biological Trace Element Research·Jing-Xiu XuJin-Long Li
Feb 27, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zi-wei ZhangShi-wen Xu
Oct 29, 2013·Lipids in Health and Disease·Yue-Hui YangQing-Hua Jiang
Mar 24, 2016·Biological Trace Element Research·Pervez Ahmed KhosoShu Li
May 15, 2015·Biological Trace Element Research·Ying GuoMingwei Xing
Feb 1, 2013·Asian-Australasian Journal of Animal Sciences·Savaram Venkata Rama RaoOrugonda Krishna Murthy
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Mar 6, 2015·Biological Trace Element Research·Pervez Ahmed KhosoShu Li
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Dec 6, 2014·Biological Trace Element Research·Dongbo SunHongbin Wang
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Oct 17, 2016·Biological Trace Element Research·Pervez Ahmed KhosoShu Li
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Mar 3, 2017·Biological Trace Element Research·Qi LiuZiwei Zhang
Jan 26, 2021·Oxidative Medicine and Cellular Longevity·Xiaoqing ChiSonghua Hu

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