Effects of oxygen tension on flow-induced vasodilation in porcine coronary resistance arterioles

Microvascular Research
A H JimenezP R Myers

Abstract

Vascular tone has been shown to be importantly influenced by flow-induced release of endothelium-derived vasodilators. The purpose of the present study was to test the hypothesis that in porcine coronary resistance-size arterioles, flow-induced vasodilation is sensitive to oxygen tension. Arterioles (55-150 mu m) were studied in vitro under conditions of constant intraluminal pressure to dynamically measure arteriolar diameter in response to changes in flow or, alternatively, in response to bradykinin under three conditions: hyperoxia (pO(2) 400 mm Hg), normoxia (pO(2) 160 mm Hg), and hypoxia (p0(2) 40 mm Hg). Under conditions of constant pressure and no flow, hypoxia alone resulted in vasodilation that was blocked by the nitric oxide synthase inhibitor omega-nitro-L-arginine methyl ester (L-NAME). Hypoxia did not alter the vasodilator response to bradykinin when compared to the vasodilator response to bradykinin during normoxia. During hyperoxia, flow-induced vasodilation was significantly reduced by either indomethacin, or L-NAME. Indomethacin and L-NAME combined completely abolished flow-induced vasodilation under conditions of hyperoxia. Under conditions of normoxia and hypoxia, indomethacin or L-NAME alone only partially b...Continue Reading

Citations

Feb 24, 2001·Hypertension·Carlos D. FigueroaWerner Müller-Esterl
Oct 26, 2005·American Journal of Physiology. Heart and Circulatory Physiology·F M LynchA S Izzard
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K RuijtenbeekJ G R De Mey
Feb 9, 2000·American Journal of Physiology. Cell Physiology·J A BurasW R Reenstra
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·B A Sauls, M A Boegehold
Oct 12, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R L FigueiraL Sbragia
Jul 7, 2000·Pharmacology & Therapeutics·T KomaruK Shirato

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