PMID: 6398782Jan 1, 1984Paper

Effects of oxygen therapy on pulmonary arterial hypertension in chronic obstructive lung disease

Giornale italiano di cardiologia
J Zielinski

Abstract

In patients suffering from chronic obstructive lung disease pulmonary arterial hypertension is mainly due to anatomical lesions. For this reason it does not regress following acute administration of oxygen, unlike functional pulmonary arterial hypertension due to vasoconstriction, which superimposes itself on the anatomical lesions during exacerbations of respiratory insufficiency. At present there is convincing proof that protracted treatment with oxygen is able to reduce pulmonary arterial hypertension sustained by anatomical alterations. Two recent studies, one carried out in the U.S. (duration of follow-up: 6 months), the other in Great Britain (duration of follow-up: 5 years), have reached this conclusion. The effects of oxygen on pulmonary arterial hypertension are directly proportional to the number of hours in which oxygen is administered daily; in any case this number should not be below 15 hours/day. The reasons for which treatment with oxygen is not able to arrest the evolution of pulmonary arterial hypertension in some patients and the role of the reduction in blood viscosity due to oxygen therapy remain to be clarified.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved