Effects of oxytocin administration on the hydromineral balance of ME-lesioned rats

Journal of Neuroendocrinology
Javier MahíaAmadeo Puerto

Abstract

In the clinical setting, acute injuries in hypothalamic mediobasal regions, along with polydipsia and polyuria, have been observed in patients with cerebral salt wasting (CSW). CSW is also characterized by hypovolemia and hyponatremia due to an early increase in natriuretic peptide activity. Salt and additional amounts of fluid are the main treatment for this disorder. Similarly, experimental lesions to these brain regions, which include the median eminence (ME), produce a well-documented neurological model of polydipsia and polyuria in rats, which is preceded by an early sodium excretion of unknown cause. In this study, OT was used to increase the renal sodium loss and prolong the hydroelectrolyte abnormalities of ME-lesioned animals during the first few hours post-surgery. The objective was to determine whether OT-treated ME-lesioned animals increase their sodium appetite and water intake to restore the volume and composition of extracellular body fluid. Electrolytic lesion of the ME increased water intake, urinary volume, and sodium excretion of food-deprived rats and decreased urine osmolality and estimated plasma sodium concentration. OT administration at 8 h post-surgery reduced water intake, urine output, and plasma sodi...Continue Reading

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