PMID: 9243706Mar 1, 1997

Effects of oxytocin, arginine-vasopressin and lysine-vasopressin on insulin and glucagon secretion in sheep

Research in Veterinary Science
H MineoN Yanaihara


The effects of the posterior-pituitary peptides oxytocin (OT), arginine-vasopressin (AVP) and lysine-vasopressin (LVP) on insulin and glucagon secretion were examined in adult sheep. Each peptide was injected intravenously at doses from 1 to 3000 pmol kg-1. All three peptides increased plasma insulin and glucagon concentrations, but their dose-response relationships revealed differences between them. The maximal insulin responses induced by OT and AVP were very similar, but the threshold and maximal doses of AVP for increasing plasma insulin were higher than those of OT. OT and AVP had the same activity for stimulating glucagon secretion in respect of the threshold and maximal doses and the maximal hormone response. LVP also increased plasma insulin and glucagon concentrations, but it had the weakest activity for stimulating both hormones. These results suggest that in sheep posterior-pituitary peptide may play a role in regulating nutrient metabolism by influencing pancreatic hormone secretion.


Jan 1, 1979·Biology of the Neonate·R I StarkR L Vande Wiele
Jan 1, 1991·Acta Obstetricia Et Gynecologica Scandinavica·M SilberK Uvnäs-Moberg
Nov 1, 1988·The American Journal of the Medical Sciences·J A AmicoJ Haldar
May 1, 1987·Acta Physiologica Scandinavica·S Stock, K Uvnäs-Moberg
Jul 1, 1985·Acta Physiologica Scandinavica·K Uvnäs-MobergA Kunavongkrit
Oct 1, 1985·Acta Physiologica Scandinavica·S Stock, K Uvnäs-Moberg
Aug 1, 1970·Endocrinology·A Kaneto, K Kosaka
Jan 1, 1983·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J Knudtzon
Oct 1, 1983·Neuroendocrinology·R E LangW Rascher
Aug 1, 1983·American Journal of Obstetrics and Gynecology·R T KellyM Morris
Dec 1, 1982·Endocrinology·Y SasakiT E Weekes
Dec 1, 1982·The Journal of Physiology·F EllendorffD A Poulain
Sep 1, 1980·The Journal of Physiology·Y Sasaki, H Takahashi
Nov 1, 1982·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M D MitchellA C Turnbull


Aug 4, 2007·The Journal of Physiology·Yoko FujiwaraAkito Tanoue
Nov 12, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Sang-Gun RohKazuo Katoh
Apr 30, 2008·Current Opinion in Anaesthesiology·Martin W Dünser, Martin Westphal

Related Concepts

Argipressin Tannate
Blood Glucose
Dose-Response Relationship, Drug
Intravenous Injections
Dall Sheep
Vasoconstrictor Agents

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.