PMID: 9243706Mar 1, 1997

Effects of oxytocin, arginine-vasopressin and lysine-vasopressin on insulin and glucagon secretion in sheep

Research in Veterinary Science
H MineoN Yanaihara

Abstract

The effects of the posterior-pituitary peptides oxytocin (OT), arginine-vasopressin (AVP) and lysine-vasopressin (LVP) on insulin and glucagon secretion were examined in adult sheep. Each peptide was injected intravenously at doses from 1 to 3000 pmol kg-1. All three peptides increased plasma insulin and glucagon concentrations, but their dose-response relationships revealed differences between them. The maximal insulin responses induced by OT and AVP were very similar, but the threshold and maximal doses of AVP for increasing plasma insulin were higher than those of OT. OT and AVP had the same activity for stimulating glucagon secretion in respect of the threshold and maximal doses and the maximal hormone response. LVP also increased plasma insulin and glucagon concentrations, but it had the weakest activity for stimulating both hormones. These results suggest that in sheep posterior-pituitary peptide may play a role in regulating nutrient metabolism by influencing pancreatic hormone secretion.

References

Jan 1, 1979·Biology of the Neonate·R I StarkR L Vande Wiele
Jan 1, 1991·Acta Obstetricia Et Gynecologica Scandinavica·M SilberK Uvnäs-Moberg
Nov 1, 1988·The American Journal of the Medical Sciences·J A AmicoJ Haldar
May 1, 1987·Acta Physiologica Scandinavica·S Stock, K Uvnäs-Moberg
Jul 1, 1985·Acta Physiologica Scandinavica·K Uvnäs-MobergA Kunavongkrit
Oct 1, 1985·Acta Physiologica Scandinavica·S Stock, K Uvnäs-Moberg
Aug 1, 1970·Endocrinology·A Kaneto, K Kosaka
Jan 1, 1983·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J Knudtzon
Oct 1, 1983·Neuroendocrinology·R E LangW Rascher
Aug 1, 1983·American Journal of Obstetrics and Gynecology·R T KellyM Morris
Dec 1, 1982·Endocrinology·Y SasakiT E Weekes
Dec 1, 1982·The Journal of Physiology·F EllendorffD A Poulain
Sep 1, 1980·The Journal of Physiology·Y Sasaki, H Takahashi
Nov 1, 1982·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M D MitchellA C Turnbull

Citations

Aug 4, 2007·The Journal of Physiology·Yoko FujiwaraAkito Tanoue
Nov 12, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Sang-Gun RohKazuo Katoh
Apr 30, 2008·Current Opinion in Anaesthesiology·Martin W Dünser, Martin Westphal

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Argipressin Tannate
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