PMID: 2099341Jan 1, 1990Paper

Effects of ozone exposure on experimental asthma in guinea pigs sensitized with ovalbumin through the airway

International Archives of Allergy and Applied Immunology
M SumitomoT Okubo

Abstract

As ozone (O3) is known to cause airway inflammation and hyperresponsiveness, we examined the effects of O3 exposure (1, 3, or 5 ppm, 2 h) on sensitization and provocation in guinea pigs sensitized with ovalbumin (OA) through the airway. In groups exposed to O3 before sensitization, 5 ppm increased the production of IgG1 antibodies and decreased the OA sensitization threshold from 0.01 to 0.002%. In those exposed before provocation, 1, 3, or 5 ppm of O3 decreased the OA provocation threshold from 0.5 to 0.02%, and this enhancement appeared to depend on airway hyperresponsiveness. We conclude that O3 exposure may play an important role in causing asthmatic attacks rather than enhancing allergic sensitization.

Citations

Aug 22, 2001·Toxicology Letters·M K IijimaN Shimojo
Nov 28, 2013·Journal of Toxicology and Environmental Health. Part a·Jitka Stilund HansenSøren Thor Larsen
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·E RouxR Marthan
Jan 15, 2011·Journal of Occupational Medicine and Toxicology·Joachim Mutter
Apr 10, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P O DepuydtR A Pauwels
Jan 28, 2004·Inhalation Toxicology·Jerold A LastNicholas J Kenyon
Jun 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S D CrowtherJ Morley

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