Effects of ozone on the epithelial and inflammatory responses in the airways: role of tumor necrosis factor

Journal of Toxicology and Environmental Health
C Young, D K Bhalla

Abstract

We have investigated the possibility that tumor necrosis factor alpha (TNF) plays a role in the increased airway permeability and an inflammatory response following an acute ozone (O3) exposure. Male Sprague-Dawley rats were injected, intraperitoneally, with either rabbit anti-mouse antibody to TNF (anti-TNF) or preimmune rabbit serum, 2 h before a 3-h exposure to O3 or purified air. Permeability, as determined by [99mTc] diethylenetriamine pentaacetate (DTPA) transport, total protein and albumin concentrations in the bronchoalveolar lavage (BAL), and the inflammatory cell response in the BAL were assessed 10 h after the exposure was completed. The O3-exposed group that was injected with anti-TNF showed a significant decrease in permeability to DTPA in comparison to the O3- exposed group injected with preimmune rabbit serum. There was no difference between the anti-TNF group and the purified air group. In contrast, the total protein and albumin levels in the BAL were significantly greater in both of the O3-exposed groups than in the purified air group. The concentrations of protein and albumin in the anti-TNF group did, however, show an attenuating trend when compared to the preimmune O3-exposed group. The polymorphonuclear leu...Continue Reading

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Citations

Feb 10, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gautam DameraReynold A Panettieri
Jun 15, 2013·Oxidative Medicine and Cellular Longevity·Hye-Youn ChoSteven R Kleeberger
Aug 25, 2001·American Journal of Respiratory and Critical Care Medicine·S A ShoreC M Doerschuk
Jan 27, 2007·American Journal of Respiratory and Critical Care Medicine·Hye-Youn ChoSteven R Kleeberger
Oct 18, 2008·American Journal of Respiratory Cell and Molecular Biology·Shigeki MatsubaraErwin W Gelfand
Dec 2, 2008·Pulmonary Pharmacology & Therapeutics·Alison S WilliamsKian Fan Chung
Feb 1, 1996·The British Journal of Radiology·A Burch, J Law

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