Effects of paclitaxel and docetaxel on EGFR-expressing human carcinoma cells under normoxic versus hypoxic conditions in vitro

Journal of Chemotherapy
I SkvortsovaT Seppi

Abstract

Human malignant tumors, such as non-small lung, breast, ovarian, head and neck, prostate, stomach and colorectal cancers express a number of growth factor receptors (e.g. EGFR or EGFR family members) that are regulated by tumor hypoxia and contribute to tumor growth and failure of cytotoxic therapy. Paclitaxel and docetaxel are indispensable substances in the treatment of these tumors. Despite the active clinical use of taxanes, little is known about their cytotoxic activity under hypoxia. The aim of the present work was to compare the cytotoxic effect of taxanes, paclitaxel and docetaxel on the EGFR-expressing carcinoma cell lines A431, MDA-MB-231 and NCI-H358 under normoxic and hypoxic conditions. The two taxanes caused different cell cycle distribution and varying aneuploid cell formation under hypoxia. EGFR-overexpressing carcinoma cells showed hypoxia to severely affect the cytotoxicity of paclitaxel, whereas docetaxel preserved its tumor cell-killing activity even at lowest concentrations (0.5 nM), as was observed for both taxanes under normoxia.

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Citations

Nov 5, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zonglei MaoXiaoqiang Dong
Jun 15, 2011·Cancer Letters·Christoph WohlkoenigHorst Olschewski
May 11, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ira SkvortsovaPeter Lukas
Mar 13, 2008·Cancer Treatment Reviews·L MarignolD Hollywood
Feb 11, 2015·Biochimica Et Biophysica Acta·Viswanath DasJohn H Miller
Aug 6, 2013·Biotechnology Advances·Joana Silva-CorreiaRui L Reis
Feb 16, 2020·Radiology and Oncology·Giulia NegroSergej Skvortsov
Jul 31, 2019·American Journal of Clinical Oncology·Vasilios PergialiotisAlexandros Rodolakis
Aug 3, 2019·International Journal of Molecular Sciences·Sabino RussiVitalba Ruggieri
May 4, 2021·Radiology and Oncology·Bertram AschenbrennerIra Skvortsova

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