Effects of paired-pulse transcranial magnetic stimulation of the motor cortex on perception of experimentally induced pain

The Clinical Journal of Pain
Veit MyliusFelix Rosenow

Abstract

We investigated the influence of paired-pulse transcranial magnetic stimulation (ppTMS) of the motor cortex (M1) on perception of noxious electrical stimuli. The nociceptive flexion reflex response was assessed to determine spinal effects. In the first experiment, the effect of ppTMS of M1 on perception of noxious stimulation of the sural nerve was assessed by varying the stimulus onset asynchronies (SOAs) and the order of the stimulations (-400, -75, -25, 25, 125, 400 ms and control ppTMS, negative sign: ppTMS precedes the noxious stimulation). Effects of a preceding ppTMS on the RII and the RIII response of the nociceptive flexion reflex were investigated for SOAs of -400 and -75 ms. The effects of ppTMS of M1 and of the occipital cortex (Oz) on noxious stimulation of the radial nerve were investigated in a second experiment. Visual analogue scales were used to assess pain intensity and unpleasantness. The results revealed increased pain unpleasantness scores for SOAs of -75, -25, 25, and 400 ms and decreased pain intensity scores for a SOA of -400 ms, when the sural nerve and M1 were stimulated. An increase of the area of the RII response was found for a SOA of -75 ms. For stimulation of the radial nerve, ppTMS of Oz but not...Continue Reading

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Citations

Dec 2, 2014·Archives of Physical Medicine and Rehabilitation·Ricardo GalhardoniDaniel Ciampi de Andrade
May 29, 2012·Pain·Veit MyliusJean-Pascal Lefaucheur
Dec 3, 2014·Depression and Anxiety·Sung Wook ChungPaul B Fitzgerald
Apr 29, 2015·European Journal of Pain : EJP·Y GranovskyA Sinai
Mar 10, 2016·Human Brain Mapping·Leonardo Christov-Moore, Marco Iacoboni

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