PMID: 6167228May 1, 1981Paper

Effects of parathyroid hormone on exocrine pancreatic secretion in parathyroidectomized dogs

Archives internationales de physiologie et de biochimie
E KleinG Ben-Ari

Abstract

The effects of intravenous parathyroid hormone (PTH) on steady state Secretin-induced pancreatic secretion were studied in seven dogs before and after parathyroidectomy. Free flow of pancreatic juice was obtained by direct cannulation of the main pancreatic duct (the minor duct being ligated) : a gastric fistula prevented the entry of gastric acid into the duodenum. In the normal dog PTH caused a significant increase in volume and bicarbonate concentration, reciprocal change in chloride and no change in total protein concentration. The stimulatory effect of PTH was dose-dependent. In the parathyroidectomized dog, the basic Secretin-induced secretion was lower than the preoperative values, but PTH infusion caused a significant increase in volume of fluids and bicarbonate concentration, reciprocal change in chloride and no change in protein concentration. These results were not dependent on calcium blood level, and did not change after calcium injection to the hypocalcemic parathyroidectomized dog. It is suggested, that PTH may have a direct effect on pancreatic exocrine secretion.

References

Oct 1, 1978·Metabolism: Clinical and Experimental·G P TellJ M Saez
Feb 1, 1972·CRC Critical Reviews in Biochemistry·H RasmussenA Tenenhouse
Sep 1, 1972·Annals of Surgery·R I DentJ E Fischer
Jun 1, 1957·Annals of Surgery·O COPEG L NARDI
Aug 1, 1959·The American Journal of Physiology·R S ALPHIN, T M LIN

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