Abstract
The roles of PTH and PTH-related peptide (PTH-rp) in the expression of matrix metalloproteinases (MMPs) during endochondral bone formation were investigated, using various cartilages obtained from young rabbits and rabbit chondrocyte cultures. Immunohistochemical, immunoblotting, zymographical, and/or Northern blot analyses showed that MMP-2 and -9 levels were much higher in the growth plate than in permanent cartilage in vivo. In growth plate chondrocyte cultures, PTH, PTH-rp, and (Bu)2cAMP increased the amount of MMP-2 present in the culture medium, as revealed by zymograms and immunoblots, whereas the other tested growth factors or cytokines, including bone morphogenetic protein-2 and interleukin-1, did not increase the MMP-2 level. PTH also increased the MMP-2 messenger RNA level within 24 h. In addition, PTH increased MMP-3 and -9 levels in the growth plate chondrocyte cultures. However, in articular chondrocyte cultures, PTH had little effect on the levels of MMP-2, -3, and -9. In contrast to PTH, interleukin-1 induced MMP-3 and -9, but not MMP-2, in growth plate and articular chondrocytes. These findings suggest that in ossifying cartilage, PTH/PTH-rp plays a pivotal role in the induction of various MMPs, including MMP-2...Continue Reading
References
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Dec 22, 1975·Calcified Tissue Research·Y ShimomuraF Suzuki
Feb 1, 1992·The Journal of Cell Biology·K BöhmeP Bruckner
Jan 1, 1991·Critical Reviews in Biochemistry and Molecular Biology·T J MartinM T Gillespie
Mar 1, 1990·The Journal of Clinical Investigation·T KoikeY Kato
Jul 1, 1990·Endocrinology·Y KatoM Iwamoto
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Y KatoK Sato
Nov 1, 1988·The Journal of Cell Biology·J L CarringtonA H Reddi
May 1, 1989·Immunology Letters·M IwamotoY Kato
Nov 1, 1987·Arthritis and Rheumatism·M E FiniC E Brinckerhoff
May 1, 1988·Endocrinology·Y KatoF Suzuki
Aug 1, 1985·The Journal of Clinical Investigation·D D DeanD S Howell
Apr 29, 1987·Biochemical and Biophysical Research Communications·M L StephensonP Angel
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y KatoY Takano
Dec 16, 1988·Science·J M WozneyE A Wang
May 1, 1987·The Journal of Cell Biology·A HinekA R Poole
Feb 28, 1972·Biochimica Et Biophysica Acta·E D Harris, S M Krane
Aug 15, 1970·Nature·U K Laemmli
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Nov 1, 1995·Developmental Biology·Q ChenP F Goetinck
Aug 1, 1995·Annals of the Rheumatic Diseases·E H KarranG P Harper
Apr 7, 1995·Science·E SchipaniH Jüppner
Apr 15, 1993·The Biochemical Journal·H P MartiD H Lovett
Dec 1, 1994·The Journal of Clinical Investigation·M B GoldringJ F Apperley
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·A KawashimaY Okada
Sep 1, 1994·The Journal of Cell Biology·N AmizukaA C Karaplis
Feb 1, 1994·The Journal of Cell Biology·C GentiliR Cancedda
Nov 1, 1993·The Journal of Clinical Investigation·Y KatoM Noshiro
Jan 1, 1994·Endocrinology·K LeeG V Segre
Feb 1, 1994·Genes & Development·A C KaraplisR C Mulligan
Jul 1, 1993·The Journal of Clinical Investigation·M MohtaiG I Goldberg
Aug 1, 1993·Developmental Biology·R T BallockM B Sporn
Apr 1, 1993·Developmental Biology·A JikkoY Kato
Jan 1, 1996·Endocrinology·A JikkoY Kato
Aug 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E M O'ByrneV S Ganu
Mar 22, 1996·Cell·C DengP Leder
Aug 2, 1996·Science·A VortkampC J Tabin
Aug 2, 1996·Science·B LanskeH M Kronenberg
Apr 1, 1996·The Biochemical Journal·R P FabunmiA C Newby
Jun 7, 1996·Biochimica Et Biophysica Acta·S MatsumotoY Masuho
Nov 1, 1996·Endocrinology·N AmizukaA C Karaplis
Nov 1, 1996·The Journal of Cell Biology·S ErdmannH Burkhardt
Jan 13, 1997·The Journal of Cell Biology·M AmlingR Baron
Citations
Jan 19, 2010·The Journal of Biological Chemistry·Christoph KlenkMartin J Lohse
Oct 9, 2003·Annals of the Rheumatic Diseases·A H Reddi
Jul 20, 1999·Molecular and Cellular Endocrinology·D A Stevens, G R Williams
Feb 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yasuyuki SasanoManabu Kagayama
Mar 31, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Kouki HatoriKeiichi Sasaki
Jul 13, 2004·International Journal of Radiation Biology·T A DamronC E Farnum
Dec 7, 2016·Clinical Medicine Insights. Endocrinology and Diabetes·Anas A AlghamdiMussa H Almalki
Aug 23, 2002·Experimental Dermatology·Emanuela MaioliConcetta Gardi
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michael J ZuscikRandy N Rosier
Apr 27, 2004·Journal of Cellular Biochemistry·Michael J ZuscikRandy N Rosier
Aug 22, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A TongE Monsonego-Ornan
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M DangeloM Pacifici
Jan 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J AlvarezJ M López
Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K HoshiH Ozawa
May 8, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E TchetinaA R Poole
May 4, 2005·Calcified Tissue International·G HaeuslerM Egerbacher
Mar 27, 2004·Endocrinology·Cheryl P Sanchez, Yu-Zhu He
Dec 7, 2000·Endocrinology·R S GoomerR Terkeltaub
Apr 4, 2017·Oncogene·J S FrielingC C Lynch
Dec 7, 2007·Cardiovascular Research·Marc-Michael ZarubaWolfgang-Michael Franz
Sep 5, 2002·Journal of Cellular Biochemistry·Silvia RiemerKlaus von der Mark
Apr 20, 2020·Experimental Physiology·Seungyong Lee, Rhonda D Prisby
Oct 23, 2003·Endocrine Reviews·Helen E TurnerJohn A H Wass
Oct 13, 2009·Endocrinology·Héloïse P Gaide ChevronnayPatrick Henriet
May 15, 2003·Endocrinology·Seicho MakihiraYukio Kato
Nov 21, 1998·Microscopy Research and Technique·A H Reddi
Feb 14, 2007·Journal of Animal Science·S SimsaE Monsonego Ornan
Aug 3, 2004·Biology of Reproduction·Emanuela MaioliAdriana Pacini
Jun 12, 2019·International Journal of Molecular Sciences·Jeremy S Frieling, Conor C Lynch
Nov 20, 2019·Indian Journal of Endocrinology and Metabolism·Geena Susan GeorgeAbilash Nair
Feb 24, 2006·Radiation Research·Timothy A DamronJoseph A Spadaro
Oct 18, 2002·The Journal of Biological Chemistry·Ming ShenYukio Kato
Oct 27, 2006·Development·Byeong S YoonKaren M Lyons
Apr 3, 2001·Experimental Cell Research·E YoshidaY Kato
Nov 2, 1999·Biochemical and Biophysical Research Communications·H SekiyaK i Seto
May 11, 2005·Osteoarthritis and Cartilage·D W BurtonR Terkeltaub
Jan 10, 2006·The American Journal of Pathology·Elena V TchetinaA Robin Poole