Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women.

The Journal of Clinical Endocrinology and Metabolism
Matthew T DrakeSundeep Khosla

Abstract

Intermittent PTH treatment stimulates bone formation, but the mechanism(s) of this effect remain unclear. Sclerostin is an inhibitor of Wnt signaling, and animal studies have demonstrated that PTH suppresses sclerostin production. The objective of the study was to test whether intermittent PTH treatment of postmenopausal women alters circulating sclerostin levels. Prospective study. The study was conducted at a clinical research unit. Participants included 27 postmenopausal women treated with PTH (1-34) for 14 d and 28 control women. Serum sclerostin levels were measured. Circulating sclerostin levels decreased significantly in the PTH-treated subjects, from (mean ± SEM) 551 ± 32 to 482 ± 31 pg/ml (-12.7%, P < 0.0001) but did not change in the control women (baseline, 559 ± 34 pg/ml; end point, 537 ± 40 pg/ml, P = 0.207; P = 0.017 for difference in changes between groups). Bone marrow plasma was obtained in a subset of the control and PTH-treated subjects (n = 19 each) at the end of the treatment period, and marrow plasma and peripheral serum sclerostin levels were significantly correlated (R = 0.64, P < 0.0001). Marrow plasma sclerostin levels were 24% lower in PTH-treated compared with control women, but perhaps due to the sm...Continue Reading

References

May 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J E OnyiaT J Martin
Jul 13, 2002·American Journal of Medical Genetics·Karen Staehling-HamptonMary E Brunkow
Apr 12, 2003·Journal of Cellular Biochemistry·Rachel M LocklinB Lawrence Riggs
Feb 19, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John C HuangRobert A Nissenson
Jul 29, 2004·JAMA : the Journal of the American Medical Association·Lorenz C Hofbauer, Michael Schoppet
May 24, 2005·The Journal of Biological Chemistry·Mikhail SemënovXi He
Jun 11, 2005·Bone·Hansjoerg Keller, Michaela Kneissel
May 4, 2006·The Journal of Clinical Investigation·Venkatesh KrishnanOrmond A Macdougald
Aug 19, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Olivier LeupinHansjoerg Keller
Dec 19, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Arunik SanyalSundeep Khosla
Feb 5, 2008·The Journal of Clinical Investigation·Sundeep KhoslaMerry Jo Oursler
Feb 14, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiaodong LiChris Paszty
Aug 14, 2008·PloS One·Charles A O'BrienTeresita Bellido
Dec 4, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiaodong LiChris Paszty
Mar 5, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael S OminskyPaul J Kostenuik
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ina KramerMichaela Kneissel
Feb 17, 2010·The Journal of Clinical Endocrinology and Metabolism·Faryal S MirzaJoseph A Lorenzo

❮ Previous
Next ❯

Citations

Feb 10, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S A PolyzosE Terpos
May 17, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A MoustafaJ S Price
May 28, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S KirmaniS Khosla
Jun 11, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y E ChungJ-M Koh
Nov 2, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M-S M ArdawiM H Qari
Apr 25, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P GarneroR D Chapurlat
Jul 18, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L R MorseR A Battaglino
Jan 30, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z E BelayaI I Dedov
Feb 23, 2013·Calcified Tissue International·Ombretta ViapianaDavide Gatti
Jun 12, 2013·Calcified Tissue International·Maurizio RossiniSilvano Adami
Mar 26, 2013·Journal of Bone and Mineral Metabolism·Harjit Pal BhattoaPeter Antal-Szalmas
Jan 12, 2012·Current Osteoporosis Reports·Aline G Costa, John P Bilezikian
Sep 18, 2012·Current Osteoporosis Reports·Ricardo A BattaglinoLeslie R Morse
Nov 2, 2011·Annales d'endocrinologie·M-A Quemerais-DurieuO Chabre
Mar 1, 2014·BoneKEy Reports·Bart L Clarke, Matthew T Drake
Feb 8, 2013·Nature Medicine·Roland Baron, Michaela Kneissel
Aug 28, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sundeep Khosla
Aug 30, 2013·Journal of Translational Medicine·Gillian WheaterJacob M van Laar
May 6, 2011·The Journal of Clinical Endocrinology and Metabolism·Melissa McNultyRajiv Kumar
Sep 23, 2011·The Journal of Clinical Endocrinology and Metabolism·Aline G CostaJohn P Bilezikian
Aug 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Elaine W YuBenjamin Z Leder
Apr 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Aarthi ArasuUNKNOWN Study of Osteoporotic Fractures Research Group
Jul 7, 2012·The Journal of Clinical Endocrinology and Metabolism·J M SpatzS M Smith
Apr 23, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Liesbeth ViaenePatrick C D'Haese
Sep 5, 2013·Calcified Tissue International·Teresita Bellido
May 7, 2013·Journal of Endocrinological Investigation·S A PolyzosE Terpos
Feb 4, 2014·European Journal of Endocrinology·Bess Dawson-HughesNancy J Palermo
Sep 29, 2012·Bone·Teresita BellidoPaola Divieti Pajevic
Feb 25, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A G CostaJ P Bilezikian
Aug 2, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K EbinaH Yoshikawa
Jul 31, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H B JiaY Wang
Feb 23, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Solenne PelletierDenis Fouque
Mar 29, 2014·Expert Opinion on Biological Therapy·Aline G CostaE Michael Lewiecki
Nov 5, 2014·Expert Opinion on Biological Therapy·Eric J CampbellDavid A Hanley
May 8, 2013·Expert Opinion on Biological Therapy·Lars Rejnmark
May 20, 2014·Expert Opinion on Biological Therapy·Salvatore Minisola
Nov 8, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Alper KirkpanturBaris Afsar
Feb 5, 2016·Biochemical and Biophysical Research Communications·Dongdong ZhangSung Kil Lim
May 23, 2012·Medicina clínica·Guillermo AlonsoManuel Muñoz-Torres
Jun 28, 2012·Biochemical and Biophysical Research Communications·Beom-Jun KimGhi Su Kim
Aug 11, 2012·Endocrinology and Metabolism Clinics of North America·Alexander V Uihlein, Benjamin Z Leder

❮ Previous
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