Effects of Parenteral Amino Acid Administration on the Postoperative Nutritional Status and Wound Healing of Protein-Malnourished Rats

Journal of Nutritional Science and Vitaminology
Akira WadaDaisuke Harada

Abstract

In Japan, parenteral nutrition (PN) solutions are frequently administered to patients in the postoperative short-term period. In these cases, amino acid-containing peripheral parenteral nutrition (PPN) solutions, amino acid-free maintenance solutions or combinations of the two are used. However, consensus regarding the most beneficial solution for these patients is lacking. Here, we examined the nutritional status and wound healing outcomes in protein-malnourished rats receiving postoperative administrations of PPN solution, maintenance solution or combinations of the two solutions. Protein malnutrition was induced in Sprague-Dawley rats by feeding an AIN-93G-based low-protein diet (5% casein) for 2 wk. After laparotomy, dorsal skin incision, and placement of a jugular vein catheter, the rats were divided into 3 groups. Each group was administered 113 kcal/kg/d, with group A receiving maintenance solutions without amino acid, group B receiving PPN with 1.5% amino acid, and group C receiving PPN with 3% amino acid. After 5 d post-operative administration, we measured the tensile strength of the wound area, skeletal muscle weights, and nutritional parameters. Significantly higher plasma nutritional parameters and gastrocnemius an...Continue Reading

References

Jul 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·D SchroederG L Hill
Oct 1, 1995·American Journal of Surgery·J T MäkeläS Laitinen
Feb 28, 2002·Bioscience, Biotechnology, and Biochemistry·Yuichi OishiTadashi Noguchi
Feb 18, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Comasia A RagusoClaude Pichard
Nov 19, 2003·JPEN. Journal of Parenteral and Enteral Nutrition·Malcolm K RobinsonDanny O Jacobs
Dec 21, 2005·The Journal of Nutrition·Satoshi Fujita, Elena Volpi
Dec 21, 2005·The Journal of Nutrition·Haroon A ChoudryWiley W Souba
Dec 7, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Kristina NormanMatthias Pirlich
Jan 19, 2008·Journal of Nutritional Science and Vitaminology·Takayuki SugawaraTakashi Nagasawa
Apr 12, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Antonio C L CamposAlessandra B Branco
Oct 28, 2011·Nutrition Reviews·Marika Leenders, Luc J C van Loon
Jul 17, 2012·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J M Reinke, H Sorg
Dec 1, 2012·The Journal of the American College of Clinical Wound Specialists·Kristin Anderson, Rose L Hamm
Dec 2, 2015·Anaesthesia·Y Ali AbdelhamidA M Deane

❮ Previous
Next ❯

Citations

May 1, 2021·Brain Sciences·Rika SuzumuraTohru Okanishi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.