PMID: 7090002Apr 1, 1982Paper

Effects of parenteral vanadium administration on pulmonary metabolism of rats

Toxicology Letters
S KacewZ Merali

Abstract

Daily, intraperitoneal administration of either vanadium pentoxide (VP) or sodium vanadate (NaV) at a dose of 1 mg/kg for 14 days produced no marked change in pulmonary protein, glycogen and phospholipid (PL) levels of adult male rats. Increasing the VP dose to 4 mg/kg decreased lung PL content, while an equivalent NaV dose elevated tissue glycogen. Treatment with either dosage of NaV elevated the activities of pulmonary 6-phosphogluconate dehydrogenase (6PGDH), pyruvate kinase (PK) and glutathione peroxidase (GP), and the higher dose increased lactate dehydrogenase (LDH) and glutathione reductase (GR). The 1 mg/kg VP produced a significant rise in glucose-6-phosphate dehydrogenase (G6PDH) and 6PGDH. while the higher VP dose in general failed to alter enzymic activity. Our data suggest that similar to intratracheal instillation, parenteral administration of vanadium exerts an effect on lung metabolism of rats.

References

Feb 1, 1978·Toxicology and Applied Pharmacology·K A ReddyC E Cross
Feb 1, 1975·Environmental Research·M D WatersD L Coffin
May 1, 1974·Toxicology and Applied Pharmacology·M D WatersD L Coffin
Sep 1, 1969·Canadian Journal of Biochemistry·R VijayvargiyaR L Singhal
Jul 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·J T MOUNTAINH E STOKINGER
Jul 1, 1959·The Journal of Clinical Investigation·G L CURRANR E BOLINGER
May 1, 1965·British Journal of Haematology·G A KOUTRASW N VALENTINE

Citations

Jun 28, 1985·Toxicology·J P Kehrer, S Kacew
Apr 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Szymon KowalskiIwona Inkielewicz-Stępniak

Related Concepts

Reduced Glutathione
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Lung
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August Rats
Vanadium

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