Effects of partial liquid ventilation on lipopolysaccharide-induced inflammatory responses in rats

Resuscitation
Milena AngelovaKoshi Makita

Abstract

To determine whether partial liquid ventilation (PLV) modified lung inflammatory response, we analyzed blood cytokine levels and cytokine mRNA expression in the lungs, using a rat model of endotoxemia. Thirty-six rats were allocated into one of four groups. The first group received conventional gas ventilation (CV group), the second group received 10 ml/kg perflubron intratracheally in combination with mechanical gas ventilation (PLV group), the third group received 20 mg/kg Escherichia coli lipopolyssacharide (LPS) intravenously in combination with mechanical gas ventilation (LPS group), and the fourth group received PLV and LPS (PLV + LPS group). Blood levels of TNF-alpha, IL-1beta, IL-6, IL-10, INF-gamma and IL-1 receptor antagonist were significantly increased in LPS and PLV + LPS groups. mRNA expression of pro- and anti-inflammatory cytokines in the lung tissue was also significantly increased in these groups. mRNA expression of IL-6 in PLV + LPS group was significantly increased in comparison with LPS group. Other cytokine mRNA expression including IL-10 and IL-1beta was also potentiated in PLV + LPS group, however this was not significant. Our results suggest that PLV does not protect the lungs against inflammation in sy...Continue Reading

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Apr 1, 2008·Expert Review of Respiratory Medicine·Hans-Joachim Lehmler

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