Effects of partial outflow obstruction on bladder contractility and blood flow to the detrusor: comparison between mild and severe obstruction

Urologia Internationalis
M SaitoA Kondo

Abstract

Detrusor dysfunction secondary to partial outflow obstruction is caused in part by decreased blood flow to the detrusor. We investigated changes in blood flow to the bladder and in bladder function after inducing partial outflow obstruction. The urethras of male Sprague-Dawley rats were constricted by sutures to degrees representing either mild and severe obstruction. Blood flow to the bladder was measured by a Doppler flowmeter prior to and 7 days after obstruction. In vivo and in vitro experiments were performed 7 days after surgery. After cystometry was used to determine bladder capacity, the pressure at which micturition was induced, and maximum voiding pressure, the bladder was removed and placed in an organ bath where increases in intravesical pressure in response to field stimulation were evaluated. Finally, volume-pressure studies were performed in order to determine passive detrusor compliance and response to field stimulation at each specific capacity in vitro. Although blood flow to the bladder was significantly decreased by severe obstruction, no differences in blood flow between control and mildly obstructed bladders was observed. While maximum voiding pressure decreased in severely obstructed bladders, both the pr...Continue Reading

Citations

Feb 22, 2002·Neurourology and Urodynamics·Anurag K DasRobert M Levin
Sep 1, 2005·International Urology and Nephrology·A ColladoH Villavicencio
Dec 21, 2002·Urology·Jacek L Mostwin
Feb 15, 2000·BJU International·M Bingöl-KologluF C Tanyel
Jul 9, 2014·Nature Reviews. Urology·Marcus J DrakeDominika A Bijos
Oct 22, 2014·Nature Reviews. Urology·Nadir I Osman, Christopher R Chapple
Feb 16, 2016·Current Urology Reports·Himanshu Aggarwal, Philippe E Zimmern
Jul 24, 2012·The Journal of Urology·Jianwen ZengSivert Lindström
Sep 10, 2008·Journal of Pediatric Surgery·Ibrahim KarnakF Cahit Tanyel
Jan 22, 2008·The Journal of Urology·Rajveer S PurohitRuhee K Sidhu
Nov 1, 2011·Neurourology and Urodynamics·Jianwen ZengSivert Lindström
Dec 8, 2011·BJU International·Seiya InoueAtsushi Takenaka
Oct 9, 2003·The Journal of Urology·Kunihiro NozakiHideki Matsui
Feb 8, 2002·The Journal of Urology·Mohamed A GhafarRalph Buttyan
May 19, 2012·Expert Opinion on Pharmacotherapy·Kang Jun Cho, Joon Chul Kim
Feb 22, 2017·Current Opinion in Urology·Reem Aldamanhori, Christopher R Chapple
Dec 23, 2017·International Urogynecology Journal·Matteo FrigerioRodolfo Milani
Apr 16, 2016·F1000Research·Nadir OsmanChristopher Chapple
Nov 17, 2004·Scandinavian Journal of Urology and Nephrology. Supplementum·Robert LevinRalph Buttyan
Feb 3, 2019·International Urogynecology Journal·Ester IllianoElisabetta Costantini
Aug 22, 2009·The American Journal of Forensic Medicine and Pathology·Dennis J ChuteKari Reiber
Aug 25, 1999·Current Opinion in Urology·J Sullivan, P Abrams
Sep 27, 2000·Current Opinion in Urology·G Hohlbrugger, C Riedl
Mar 14, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Jefferson Kalil, Carlos Arturo Levi D Ancona
Oct 26, 1999·Neurourology and Urodynamics·M A HassR M Levin
Oct 23, 2019·The Journal of Pharmacology and Experimental Therapeutics·M Silva-RamosP Correia-de-Sá
Aug 23, 2019·Neurourology and Urodynamics·Siobhan M HartiganRoger R Dmochowski
Oct 23, 2020·Lower Urinary Tract Symptoms·Kareman EljamalToshiyuki Sasaguri

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