Effects of partial ventilatory support modalities on respiratory function in severe hypoxemic lung injury

Critical Care Medicine
Dietrich HenzlerRalf Kuhlen

Abstract

The early phase of acute respiratory distress syndrome (ARDS) is characterized by impaired respiratory mechanics, ventilation-perfusion mismatch, and severe hypoxemia. Partial ventilatory support can effectively unload the respiratory workload and improve pulmonary gas exchange with less hemodynamic compromise. The partial ventilatory support mode most indicated in early phases of ARDS has not been determined. This study compares the effects of assisted ventilatory techniques on breathing pattern, gas exchange, hemodynamic function, and respiratory effort with those of controlled mechanical ventilation in similarly sedated subjects. Prospectively randomized crossover animal study. Animal research laboratory. Eleven anesthetized and mechanically ventilated pigs. Acute lung injury was induced by lung lavage. Pressure-controlled ventilation (PCV), pressure-controlled assisted ventilation (P-ACV), bilevel positive airway pressure (BIPAP), and pressure support ventilation (PSV) with equal airway pressures and sedation were applied in random order. Gas exchange, respiratory effort, and hemodynamic function were measured, and ventilation-perfusion distributions were calculated by multiple inert-gas-elimination techniques. The results ...Continue Reading

Associated Clinical Trials

References

May 1, 1974·Journal of Applied Physiology·P D WagnerJ B West
Jul 1, 1995·Intensive Care Medicine·A AlbertiA Rossi
Apr 1, 1994·Anesthesiology·G HedenstiernaB Brismar
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·C PutensenF A López
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·J L DiehlL Brochard
Feb 2, 2000·Intensive Care Medicine·R Kuhlen, C Putensen
Mar 21, 2000·The American Journal of Medicine·M Wolf
Jun 2, 2000·Critical Care Medicine·M CeredaA Pesenti
Jul 4, 2001·American Journal of Respiratory and Critical Care Medicine·C PutensenN Mutz
May 29, 2002·Anesthesia and Analgesia·Rolf DembinskiRalf Kuhlen
Jul 29, 2003·Anesthesiology·Hermann WriggeGöran Hedenstierna
Jun 18, 2004·American Journal of Respiratory and Critical Care Medicine·Catherine S H SassoonVincent J Caiozzo

❮ Previous
Next ❯

Citations

Dec 19, 2007·Intensive Care Medicine·Enrico CalziaPaolo Pelosi
Oct 18, 2013·Intensive Care Medicine·Matthieu SchmidtAlexandre Demoule
Oct 23, 2012·American Journal of Respiratory Cell and Molecular Biology·Stephen FröhlichPaul McLoughlin
Nov 5, 2008·Critical Care : the Official Journal of the Critical Care Forum·Dirk VarelmannHermann Wrigge
Jun 9, 2009·Critical Care : the Official Journal of the Critical Care Forum·Onnen MoererPaolo Pelosi
Mar 18, 2010·Critical Care : the Official Journal of the Critical Care Forum·Marcelo Gama de AbreuEdmund Koch
Jun 16, 2010·Critical Care : the Official Journal of the Critical Care Forum·Pedro L SilvaPatricia R M Rocco
Feb 25, 2011·Critical Care : the Official Journal of the Critical Care Forum·Dietrich Henzler
Aug 24, 2012·PloS One·Sarah M McMullenUNKNOWN Canadian Critical Care Trials Group (CCCTG)
Sep 19, 2015·Experimental Lung Research·Mario MenkDavid Schwaiberger
Mar 27, 2010·Experimental Lung Research·Rolf DembinskiRalf Kuhlen
Feb 22, 2011·Respiratory Physiology & Neurobiology·M CzaplikJ Bickenbach
Jul 20, 2010·Respiratory Physiology & Neurobiology·Johannes BickenbachRolf Rossaint
May 17, 2011·Critical Care Medicine·Matthieu SchmidtTarek Sharshar
May 9, 2015·Critical Care : the Official Journal of the Critical Care Forum·Yuda SutherasanUNKNOWN VENTILA GROUP
Jul 24, 2012·Respiratory Physiology & Neurobiology·Michael CzaplikJohannes Bickenbach
Dec 18, 2013·Current Opinion in Critical Care·Andreas GüldnerMarcelo Gama de Abreu
Jun 29, 2011·European Journal of Anaesthesiology·Christian S Bruells, Rolf Rossaint
Apr 14, 2017·American Journal of Respiratory and Critical Care Medicine·Peter RadermacherAlain Mercat
Apr 19, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Michaela Kollisch-SinguleNader M Habashi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.