Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
M I CorderoC Sandi

Abstract

Early-life stress and biological predispositions are linked to mood and personality disorders related to aggressive behavior. We previously showed that exposure to peripubertal stress leads to increased anxiety-like behaviors and aggression against males and females, as well as increased aggression against females in their male offspring. Here, we investigated whether paternal (pS) and individual (iS) exposure to peripubertal stress may exert additive effects on the long-term programming of anxiety-like and aggressive behaviors in rats. Given the key role of the lateral septum (LS) in the regulation of anxiety and aggressive behaviors and the hypothesized alterations in balance between neural excitation and inhibition in aggression-related disorders, markers for these processes were examined in the LS. Peripubertal stress was applied both in naïve male rats and in the offspring of peripubertally stressed males, and anxiety-like and aggressive behaviors were assessed at adulthood. Proton magnetic resonance spectroscopy at 6-months, and post-mortem analysis of glutamic acid decarboxylase 67 (GAD67) at 12-months were conducted in LS. We confirmed that aggressive behavior was increased by pS and iS, while only iS increased anxiety-...Continue Reading

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Citations

Jul 3, 2018·The European Journal of Neuroscience·Sophie E WalkerCarmen Sandi
Feb 15, 2019·Nature Reviews. Neuroscience·Ruth FeldmanFrances A Champagne
Jan 23, 2020·NMR in Biomedicine·Nathalie Just
Jun 27, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Aurelie PapilloudCarmen Sandi
Nov 29, 2020·BMC Biology·Joanna RutkowskaShinichi Nakagawa
Aug 31, 2019·Neurobiology of Stress·Nuria DaviuAnna Beyeler
Dec 22, 2020·Neurobiology of Stress·S TzanoulinouC Márquez

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