Effects of paternal occupation exposure to formaldehyde on reproductive outcomes

Journal of Occupational and Environmental Medicine
Hai-Xu WangWen-Bao Zhao

Abstract

To investigate whether paternal occupational exposure to formaldehyde (FA) affects the reproductive outcomes. Data were collected from 302 male workers occupationally exposed to FA and 305 referent controls through interview questionnaires. Formaldehyde exposure level was measured and calculated for every subject. Different reproductive outcomes were compared for two groups by logistic regression analyses. A significant increased risk of prolonged time to pregnancy (P = 0.034; odds ratio, 2.828; 95% confidence interval, 1.081 to 7.406) and significant elevated risk of spontaneous abortion (P = 0.021; odds ratio, 1.916; 95% confidence interval, 1.103 to 3.329) were observed in wives of male workers occupationally exposed to FA after correction for confounding factors. Moreover, reproductive toxicity due to FA exposure is dose dependent. This epidemiological study adds some evidence for the hypothesis that paternal FA occupation exposure has adverse effects on reproductive outcomes.

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Citations

Nov 28, 2012·Archives of Toxicology·Gunnar Damgård NielsenPeder Wolkoff
Oct 22, 2013·Environmental Toxicology·Shui-Ping HanLi Lei
Aug 1, 2015·Toxicology and Industrial Health·Jing FangDang-Xia Zhou
Mar 12, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jia ShiHao Kang
Apr 17, 2015·Chinese Journal of Integrative Medicine·Li-Ying ZhouShu-Yu Wang
Dec 17, 2020·Inhalation Toxicology·Pan GeDang-Xia Zhou
Jul 16, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Pan GeDang-Xia Zhou

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