Effects of pearl powder extract and its fractions on fibroblast function relevant to wound repair

Pharmaceutical Biology
Dai Jian-PingJiang Li-Li

Abstract

The water soluble matrix (WSM) of pearl powder [Hyriopsis cumingii Lea (Unionidae)] was extracted, and the insoluble residue was demineralized, size-fractionated, and named as MR14 (> 14 kDa), MR3-14 (3-14 kDa), and MR3 (< 3 kDa). The effects of WSM, MR14, MR3-14, and MR3 on primary mouse oral fibroblast proliferation, collagen accumulation, matrix metalloproteinase-2, -9 (MMP-2, -9) activities, and tissue inhibitor of metalloproteinase-1 (TIMP-1) production were tested by MTT assay, chloramine T method, gelatin zymography, and enzyme-linked immunosorbent assay (ELISA), respectively. The results showed that the WSM and MR14 could significantly (p < 0.05) promote fibroblast proliferation; all of the fractions could significantly promote collagen accumulation; MR14 significantly (p < 0.05) inhibited MMP-2 activity; and all of the fractions could significantly promote TIMP-1 production. This study has proved that the mechanism by which pearl powder promotes wound healing is partly due to its ability to stimulate fibroblast mitosis, collagen deposition, and TIMP-1 production, and the major active fraction may be MR14.

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Citations

Jan 31, 2016·Journal of Ethnopharmacology·Jing-Xian ZhangDe-An Guo
Sep 6, 2011·Actas dermo-sifiliográficas·M Velasco
Oct 10, 2012·Pharmaceutical Biology·Yi-Chen LiTai-Horng Young
Jul 31, 2016·The Science of the Total Environment·Alexandra ZieritzSuzanne McGowan
Feb 25, 2015·Journal of Separation Science·Jingxian ZhangDe-an Guo
Apr 6, 2019·Drug Development and Industrial Pharmacy·Xi ChenJian-Qing Gao
Feb 27, 2020·Journal of Cosmetic Dermatology·Julie K NguyenJared Jagdeo
May 8, 2021·Frontiers in Bioengineering and Biotechnology·Jingying PeiPeilong Sun

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