Effects of Pelargonium sidoides extract on chemokine levels in nasal secretions of patients with non-purulent acute rhinosinusitis.

Journal of Drug Assessment
Aleksandar PericDanilo Vojvodić

Abstract

Previous investigations suggest the use of extract from the roots of Pelargonium sidoides (EPs 7630) for improvement of the symptoms of uncomplicated upper airway inflammations, due to its antimicrobial and immunomodulatory actions. The aim of this investigation was to evaluate the effects of EPs 7630 on chemokine production in nasal mucosa and clinical parameters of patients with acute postviral rhinosinusitis (APRS). Twenty-six (n = 26) APRS patients and 25 (n = 25) control subjects were included in this prospective study. We measured the concentrations of thirteen chemokines in nasal secretions of APRS patients and controls by flow cytometry. The patients with APRS were treated by EPs 7630 20 mg oral tablets, three times daily for 10 days. We compared the chemokine levels in nasal secretions, nasal symptoms and endoscopic findings in patients, before and after therapy. We found higher Total Symptom Score (TSS) and higher concentrations of MCP-1, MIP-1α, MIP-1β, MIP-3α, ENA-78 and IL-8 in nasal secretions of APRS patients than in controls. After therapy by EPs 7630, we found significant improvement in all symptoms and endoscopic findings of APRS. The concentrations of MCP-1, IP-10 and MIP-1β were significantly increased and l...Continue Reading

References

Jan 12, 1999·American Journal of Rhinology·C RudackC Bachert
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer H DufourAndrew D Luster
Oct 29, 2002·Cytokine & Growth Factor Reviews·Patricia MentenJo Van Damme
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Aug 19, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Hugo J de BoerRonald H B Meyboom
Dec 19, 2015·International Forum of Allergy & Rhinology·Aleksandar PerićDanilo Vojvodić
Dec 29, 2015·Current Allergy and Asthma Reports·Kathrin Scheckenbach, Martin Wagenmann
Jan 29, 2019·Acta Oto-laryngologica·Jonas Jae-Hyun ParkDavid Ulrich Seidel
Aug 14, 2019·International Forum of Allergy & Rhinology·Stephen Shih-Teng KaoSarah Vreugde

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Citations

Mar 16, 2021·Vestnik otorinolaringologii·E V NosulyaM A Yushkina

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BETA
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Software Mentioned

Statistical Package for the Social Sciences
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