Effects of penicillin on group A streptococci: loss of viability appears to precede stimulation of release of lipoteichoic acid.

Antimicrobial Agents and Chemotherapy
R E Kessler, I van de Rijn

Abstract

The rate of killing of a group A streptococcal species by penicillin was compared with the release of lipoteichoic acid (LTA) and its deacylated derivative, dLTA. Although there was no stimulation of release from stationary-phase cells in the presence of penicillin, there was dramatic release of LTA and dLTA from exponential-phase cells after the addition of penicillin. Although decreases in viability were observed within 15 min after addition of penicillin, culture mass and LTA content did not appear to be affected until after 30 min. Stimulation of release of LTA and dLTA appeared to take place after 15 but before 30 min after addition of penicillin. These observations are interpreted to indicate that the stimulation of release of LTA and dLTA in response to penicillin is secondary to the killing event.

References

Dec 1, 1975·Biochemical and Biophysical Research Communications·R F ClevelandG D Shockman
Sep 1, 1979·Reviews of Infectious Diseases·G D ShockmanM Mychajlonka
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P Owen, M R Salton
Dec 1, 1979·Infection and Immunity·I van de Rijn, R E Kessler
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J V Höltje, A Tomasz
Sep 1, 1976·Journal of Bacteriology·R F ClevelandG D Shockman
May 1, 1977·Antimicrobial Agents and Chemotherapy·D Horne, A Tomasz
Apr 1, 1980·Antimicrobial Agents and Chemotherapy·M MychajlonkaG D Shockman
Feb 1, 1980·Infection and Immunity·I van de Rijn, R E Kessler
Feb 1, 1965·Analytical Biochemistry·C B LAURELL

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Citations

Jan 1, 1985·Pharmacology & Therapeutics·D J Tipper
Mar 31, 2010·PloS One·Izabela SitkiewiczJames M Musser
Oct 5, 2011·International Journal of Medical Microbiology : IJMM·Sabine GröbnerBerit Schulte
Nov 1, 1988·Infection and Immunity·M M CowanR J Doyle

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