Effects of pentoxifylline on pulmonary function and results of cytologic examination of bronchoalveolar lavage fluid in horses with recurrent airway obstruction

American Journal of Veterinary Research
Renaud LéguilletteJean-Pierre Lavoie

Abstract

To determine the effects of pentoxifylline (PTX) administration on lung function and results of cytologic examination of bronchoalveolar lavage fluid in horses affected by recurrent airway obstruction (RAO). 10 RAO-affected horses. 6 horses were orally administered PTX (16 g) mixed with corn syrup, and 4 horses were administered corn syrup alone, twice daily for 14 days. Pulmonary function was evaluated before administration (day 0) and on days 8 and 15. Bronchoalveolar lavage (BAL) was performed on days 0 and 15. Reversibility of airway obstruction was assessed by measuring pulmonary function before and after administration of atropine (0.02 mg/kg, IV). Serum concentration of PTX was measured in 4 horses 30 minutes and 2 and 4 hours after administration of PTX on days 1, 2, 3, 7 and 14. Administration of PTX to BAO-affected horses resulted in a decrease in elastance value on day 8 and on elastance and resistance (RL) values on days 8 and 15. Results for cytologic examination of BAL fluid obtained on day 15 did not differ significantly, compared with values for day 0. Values of RL decreased in all horses following administration of atropine. When mixed in corn syrup and administered orally, PTX was poorly absorbed in horses, an...Continue Reading

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Citations

Aug 10, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mathilde LeclereJean-Pierre Lavoie
Nov 3, 2006·American Journal of Veterinary Research·Renaud Léguillette, Jean-Pierre Lavoie
Dec 7, 2007·American Journal of Veterinary Research·Bettina DunkelFiona M Cunningham
Jan 26, 2016·Journal of Veterinary Internal Medicine·L L CouëtilE A Richard
Jul 26, 2008·The Veterinary Clinics of North America. Equine Practice·Andrew M Hoffman
Jul 10, 2007·The Veterinary Clinics of North America. Equine Practice·Katherine K Williamson, Michael S Davis
Oct 30, 2013·Equine Veterinary Journal·R S Pirie
May 16, 2003·The Veterinary Clinics of North America. Equine Practice·Renaud Léguillette
Jan 27, 2004·The Veterinary Clinics of North America. Equine Practice·Samuel L Jones
Jun 3, 2014·Experimental and Molecular Pathology·Vasanthi R SunilDebra L Laskin
Mar 16, 2017·Equine Veterinary Journal·L CalzettaM G Matera
Jun 2, 2017·Journal of Veterinary Internal Medicine·R LéguilletteK J McDonald
Oct 9, 2018·Journal of Veterinary Internal Medicine·Stephanie BondR Scott Pirie
Sep 27, 2018·Equine Veterinary Journal·E M MartinJ L Davis
Nov 28, 2013·American Journal of Veterinary Research·Megan R WilliamsJohn A Stick
Dec 3, 2016·American Journal of Veterinary Research·Daniela HernandezTracy Stokol
Jan 6, 2017·Mediators of Inflammation·Ann Kristin Barton, Heidrun Gehlen

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