PMID: 9646686Jan 1, 1997Paper

Effects of pentoxifylline on some peripheral blood parameters and haemostasis in acute pulmonary tissue injury after cyclophosphamide

Roczniki Akademii Medycznej W Białymstoku = Annales Academiae Medicae Bialostocensis
M SulkowskaM Sobaniec-Lotowska

Abstract

Cyclophosphamide (CP) is one of the widely used cytostatic drugs, with a strong toxic influence on pulmonary tissue. Experimental works have shown that a single high dose of CP causes injury to all elements of the interalveolar septum, especially to the alveolar endothelial and epithelial cells. The aim of this work was to evaluate the influence of pentoxifylline (PTXF) (30 mg/kg b.w.) on the ultrastructure of lungs capillaries and blood cell count as well as plasma fibrinogen levels in Wistar rats after intraperitoneal injection of 150 mg/b.w. CP. We established that in the doses applied PTXF had no statistically significant influence on the number of leukocytes and erythrocytes determined in the left ventricular blood of rats receiving CP, while the number of white cells from animals given PTXF only was higher than in controls. There was a smaller decrease in the number of platelets (p < 0.05) and smaller reduction in fibrinogen level (p < 0.01) in the serum of PTXF-CP animals than in the CP group. The results obtained suggest a protective effect of PTXF on CP induced changes, which have been evidenced in some of the parameters examined. Ultrastructural examinations found the lungs to be the organ of extramedullary thrombocyt...Continue Reading

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Roczniki Akademii Medycznej W Białymstoku = Annales Academiae Medicae Bialostocensis
B MusiatowiczE Jabłońska
Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
M SulkowskaR Farbiszewski
Roczniki Akademii Medycznej W Białymstoku = Annales Academiae Medicae Bialostocensis
S Sulkowski
© 2022 Meta ULC. All rights reserved