Effects of peptide 6A on coronary blood flow dynamics in canine coronary thrombosis

Journal of Cardiovascular Pharmacology
J L MehtaT G Saldeen

Abstract

Intracoronary thrombi resulting in acute myocardial ischemia can often be lysed by thrombolytic agents. We examined the potential of a fibrin(ogen)-degradation product pentapeptide 6A (Ala-Arg-Pro-Ala-Lys), which increases coronary blood flow partly by stimulation of prostacyclin release, in reestablishing coronary blood flow in dogs with experimentally induced thrombus. An occlusive thrombus in the circumflex coronary artery was created by electrical stimulation of the endothelial surface. After the occlusive thrombus was stable without electrical current for at least 15 min, peptide 6A (5 mumol/min for 20 min intracoronary) or tissue-plasminogen activator (t-PA) [10 micrograms/kg/min for 20 min intravenously (i.v.)] was randomly administered. Peptide 6A administration reestablished coronary blood flow (peak 16 +/- 2 ml/min, mean +/- SE) in 6 of 12 animals with occlusive coronary thrombus. Mean time to blood flow reestablishment was 5.3 +/- 2.2 min, but the reflow was short lived (mean duration of reflow: 15.7 +/- 1.6 min). t-PA reestablished coronary blood flow (peak 19 +/- 3 ml/min) in 4 of 10 animals. The time of flow reestablishment was 12.0 +/- 3.9 min and the reflow persisted for 22.0 +/- 3.1 min. Peptide 6A administrati...Continue Reading

Citations

Mar 1, 1991·Journal of the American College of Cardiology·J L MehtaT G Saldeen
Jul 1, 1991·Acta Physiologica Scandinavica·K SaldeenJ Mehta
Jul 16, 2008·International Journal of Pharmaceutics·Mei YangShiqi Peng
Feb 1, 1993·American Heart Journal·T G SaldeenJ L Mehta
Nov 8, 2003·Bioorganic & Medicinal Chemistry·Ming ZhaoShiqi Peng
Nov 22, 2000·Journal of Internal Medicine·G Rasmanis, C Sylvén
Dec 7, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ming ZhaoShiqi Peng

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