Effects of peptide YY(3-36) on PRL secretion: pituitary and extra-pituitary actions in the rat

Peptides
E AguilarL Pinilla

Abstract

Polypeptide YY(3-36) (PYY(3-36)) is a gastrointestinal secreted molecule, agonist of neuropeptide Y (NPY) receptor subtypes Y2 and Y5, that has been recently involved as anorexigenic signal in the network controlling food intake. Notably, several factors primarily involved in food intake control and energy homeostasis (as leptin, orexins, ghrelin and NPY) have been linked also to the regulation of anterior pituitary hormone secretion and carry out pleiotropic effects upon the reproductive axis. However, whether similar actions are conducted by PYY(3-36) remains so far largely unexplored. Present studies were undertaken to analyze the potential effects of PYY(3-36) in the control of prolactin (PRL) secretion in the rat. To this end, responses to PYY(3-36) in terms of PRL secretion were monitored in vitro, after pituitary exposure to 10(-8) to 10(-6) M concentrations, and in vivo, after i.p. administration of different doses of PYY(3-36) (3, 10 and 30 microg/kg) to prepubertal male and female rats. In addition, the in vivo effects of PYY(3-36) were tested after central (i.c.v.) administration of 3 nmol of the peptide to prepubertal rats, and in hyperprolactinaemic aged females. PYY(3-36) stimulated, in a dose-dependent manner, in...Continue Reading

References

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Citations

Dec 5, 2013·Journal of Molecular Endocrinology·Yoshihiro SuzukiNoboru Murakami
Dec 3, 2013·Regulatory Peptides·María Paula Di YorioAlicia Graciela Faletti
Mar 13, 2012·American Journal of Medical Genetics. Part a·Antonella FabrettoPaolo Gasparini
Jul 30, 2008·Nutrition·Ryo MorimotoKazuhiro Takahashi
Apr 6, 2006·Cultural Diversity & Ethnic Minority Psychology·Tatiana PerrinoKristopher Arheart
Mar 6, 2007·Reviews in Endocrine & Metabolic Disorders·Felecia Cerrato, Stephanie B Seminara

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