Effects of perinatal asphyxia on the mesostriatal/mesolimbic dopamine system of neonatal and 4-week-old male rats

Experimental Brain Research
U UngethümK Andersson

Abstract

The present study was undertaken in order to study the effects of perinatal asphyxia on tyrosine hydroxylase (TH) activity, dopamine levels and turnover, and dopamine metabolites (3,4-dihydroxyphenylacetic acid, DOPAC, homovanillic acid, HVA, and 3-methoxytyramine, 3-MT, analyzed by high-performance liquid chromatography, HPLC) measured in the basal ganglia of the 20- to 40-min-old newborn and 4-week-old male rat. Asphyxia was induced in pups by placing the fetuses, still in their uterus horns removed by hysterectomy from pregnant rats at full term, in a 37 degrees C water bath for 15-16 min or 19-20 min. Following asphyxia, the uterus horns were opened, and the pups were removed and stimulated to breathe. A 100% and 50-80% pup survival was obtained following 15-16 min and 19-20 min of asphyxia, respectively. Acute changes were studied in brains from newborn pups 20-40 min after delivery, and long-term changes were studied in brains from 4-week-old rats. No changes in TH-activity could be observed in the substantia nigra/ventral tegmental area (SN/VTA), the striatum, or the accumbens nucleus/olfactory tubercle (ACC/TUB), in the newborn or the 4-week-old rat. In the newborn rat, 19-20 min of asphyxia increased (as compared to co...Continue Reading

Citations

Jan 14, 2003·Sleep & Breathing = Schlaf & Atmung·Michael J Decker, David B Rye
Jul 21, 2010·Neurotoxicity Research·Mario Herrera-MarschitzPeter J Gebicke-Haerter
Apr 19, 2015·Journal of Biomedical Science·Silvia J López-PérezLaura Medina-Ceja
Apr 12, 2014·Frontiers in Neuroscience·Mario Herrera-MarschitzPeter J Gebicke-Haerter
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Feb 28, 2016·Behavior Genetics·Taylor F SmithValerie S Knopik
Nov 30, 2018·Journal of Psychopharmacology·Tracey A LarsonRyan K Bachtell

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