Abstract
The present study was undertaken in order to study the effects of perinatal asphyxia on tyrosine hydroxylase (TH) activity, dopamine levels and turnover, and dopamine metabolites (3,4-dihydroxyphenylacetic acid, DOPAC, homovanillic acid, HVA, and 3-methoxytyramine, 3-MT, analyzed by high-performance liquid chromatography, HPLC) measured in the basal ganglia of the 20- to 40-min-old newborn and 4-week-old male rat. Asphyxia was induced in pups by placing the fetuses, still in their uterus horns removed by hysterectomy from pregnant rats at full term, in a 37 degrees C water bath for 15-16 min or 19-20 min. Following asphyxia, the uterus horns were opened, and the pups were removed and stimulated to breathe. A 100% and 50-80% pup survival was obtained following 15-16 min and 19-20 min of asphyxia, respectively. Acute changes were studied in brains from newborn pups 20-40 min after delivery, and long-term changes were studied in brains from 4-week-old rats. No changes in TH-activity could be observed in the substantia nigra/ventral tegmental area (SN/VTA), the striatum, or the accumbens nucleus/olfactory tubercle (ACC/TUB), in the newborn or the 4-week-old rat. In the newborn rat, 19-20 min of asphyxia increased (as compared to co...Continue Reading
Citations
Oct 20, 2006·Experimental Brain Research·Diego BustamanteMario Herrera-Marschitz
Jan 14, 2003·Sleep & Breathing = Schlaf & Atmung·Michael J Decker, David B Rye
Jul 21, 2010·Neurotoxicity Research·Mario Herrera-MarschitzPeter J Gebicke-Haerter
Feb 18, 1998·Brain Research. Developmental Brain Research·Y ChenM Herrera-Marschitz
Aug 5, 2000·Brain Research. Molecular Brain Research·J GrossK Andersson
Aug 23, 2003·Neuroscience Letters·P MoralesM Herrera-Marschitz
Jan 17, 1997·Neuroscience Letters·Y ChenK Andersson
Nov 11, 1999·Neuroscience Letters·B HusemannJ Gross
Mar 5, 2003·Neuroscience·M J DeckerD B Rye
Jul 17, 1999·Neuroscience·J GrossK Andersson
Apr 12, 2008·Experimental Neurology·E StrackxA W D Gavilanes
Mar 1, 2013·Synapse·Pablo GaleanoEduardo Blanco
Apr 20, 2005·Brain Research. Molecular Brain Research·Johann GrossMario Herrera-Marschitz
Jun 16, 2004·Neuroscience Letters·Peter BrustReinhard Bauer
Apr 19, 2015·Journal of Biomedical Science·Silvia J López-PérezLaura Medina-Ceja
Apr 12, 2014·Frontiers in Neuroscience·Mario Herrera-MarschitzPeter J Gebicke-Haerter
Dec 23, 2009·Neuroscience and Biobehavioral Reviews·Dustin WahlstromMonica Luciana
Feb 28, 2016·Behavior Genetics·Taylor F SmithValerie S Knopik
Jul 18, 2003·Pediatric Research·Guenther BernertBarbara Lubec
Nov 30, 2018·Journal of Psychopharmacology·Tracey A LarsonRyan K Bachtell