Effects of perinatal blood pressure on maternal brain functional connectivity

PloS One
Hiromichi KurosakiYoshiki Kaneoke

Abstract

Perinatal hypertensive disorder including pre-eclampsia is a systemic syndrome that occurs in 3-5% of pregnant women. It can result in various degrees of brain damage. A recent study suggested that even gestational hypertension without proteinuria can cause cardiovascular or cognitive impairments later in life. We hypothesized that perinatal hypertension affects the brain functional connectivity (FC) regardless of the clinical manifestation of brain functional impairment. In the present study, we analyzed regional global connectivity (rGC) strength (mean cross-correlation coefficient between a brain region and all other regions) using resting-state functional magnetic resonance imaging to clarify brain FC changes associated with perinatal blood pressure using data from 16 women with a normal pregnancy and 21 pregnant women with pre-eclampsia. The rGC values in the bilateral orbitofrontal gyri were negatively correlated with diastolic blood pressure (dBP), which could not be explained by other pre-eclampsia symptoms. The strength of FC seeding at the left orbitofrontal gyrus was negatively correlated with dBP in the anterior cingulate gyri and right middle frontal gyrus. These results suggest that dBP elevation during pregnancy ...Continue Reading

References

Aug 1, 1992·AJR. American Journal of Roentgenology·R B SchwartzB L Holman
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Mar 1, 1994·Stroke; a Journal of Cerebral Circulation·M J MentisS I Rapoport
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Mar 26, 2002·Brain : a Journal of Neurology·F-E de LeeuwM M B Breteler
May 28, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K Williams, F Galerneau
Feb 9, 2005·Physical Review Letters·Victor M EguíluzA Vania Apkarian
Jun 11, 2005·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Shari R WaldsteinLeslie I Katzel
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Sep 21, 2005·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Mehmet A OsmanağaoğluHasan Bozkaya
Jun 6, 2007·Hypertension·Marilyn J Cipolla
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marwan N BalikiDante R Chialvo
Sep 19, 2008·Acta Neurologica Scandinavica·K HannesdottirH S Markus
Oct 8, 2008·Methods in Molecular Biology·Bharat B Biswal, Sridhar S Kannurpatti
Apr 3, 2009·Journal of Neurophysiology·Michael D FoxMarcus E Raichle
Oct 24, 2009·American Journal of Obstetrics and Gynecology·Stefan VerlohrenHolger Stepan
Nov 17, 2009·NeuroImage·Michael W ColeWalter Schneider
Jan 19, 2010·Annual Review of Pathology·Brett C YoungS Ananth Karumanchi
May 27, 2010·Brain Imaging and Behavior·Ananth NarayananDavid Q Beversdorf
Jul 31, 2010·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Tiina Podymow, Phyllis August
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alex FornitoEdward T Bullmore
Apr 27, 2011·Acta Physiologica·C AalkjærV Matchkov
Sep 9, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roy SalomonRafael Malach
Apr 25, 2012·Frontiers in Psychiatry·Alex Fornito, Edward T Bullmore
Jun 6, 2012·PloS One·Yoshiki KaneokeMasaki Terada
Aug 28, 2013·Neurologia Medico-chirurgica·Yasumasa OhnoFumitaka Kikkawa
Jan 31, 2014·Current Atherosclerosis Reports·Amanda R Vest, Leslie S Cho
Apr 12, 2014·AJNR. American Journal of Neuroradiology·V JunewarA Parihar
May 3, 2014·Obstetrics and Gynecology·Marjon J WiegmanJan C de Groot
May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Genevieve J YangAlan Anticevic
Oct 21, 2014·The Journal of Clinical Investigation·Xiujun FanNihar R Nayak
Dec 3, 2014·NeuroImage·Jonathan D PowerSteven E Petersen
Dec 20, 2014·Human Brain Mapping·Dustin ScheinostR Todd Constable
Jul 16, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David C ZhuRong Zhang
Jan 7, 2016·The New England Journal of Medicine·Harald ZeislerStefan Verlohren
Oct 19, 2016·NeuroImage·Jonathan D PowerAlex Martin
Mar 23, 2017·American Journal of Obstetrics and Gynecology·Julie A FieldsVirginia M Miller
May 16, 2017·Pregnancy Hypertension·P Soma-PillayR C Pattinson

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

SPM8
MATLAB
SnPM
CompCor

Related Concepts

Related Feeds

Brain Imaging of Neural Circuits

Neural circuits are groups of interconnected neurons which carry out specific functions when activated. Imaging these neural circuits allows researches to further elucidate their mechanisms and functions. Follow this feed to stay up to date on brain imaging of neural circuits.

Brain Imaging of Neural Circuits (MDS)

Neural circuits are groups of interconnected neurons which carry out specific functions when activated. Imaging these neural circuits allows researches to further elucidate their mechanisms and functions. Follow this feed to stay up to date on brain imaging of neural circuits.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.