Effects of perinatal exposure to BPA and its alternatives (BPS, BPF and BPAF) on hepatic lipid and glucose homeostasis in female mice adolescent offspring

Chemosphere
Zhiyuan MengWentao Zhu

Abstract

The widespread application of bisphenols (BPs) makes them ubiquitous in the natural environment and poses many potential risks. In this study, we examined the effects of perinatal exposure to BPA and its 3 alternatives (BPS, BPF, and BPAF) on lipid and glucose homeostasis in female mice adolescent offspring. Specifically, BPA exposure promoted the expression of hepatic lipid synthesis and fatty acid accumulation genes, resulting in a significant increase in 2 free fatty acids contents. BPS exposure caused an increase in 6 free fatty acids and triglyceride contents through promoting the expression of fatty acid synthesis, triglyceride synthesis and fatty acid accumulation genes and inhibiting the expression of fatty acid β-oxidation genes. Interestingly, BPAF exposure showed completely opposite effects on hepatic lipid metabolism compared to BPS exposure. 9 free fatty acids and triglycerides contents in the liver were significantly reduced. In particular, BPF exposure caused decreases in 2 free fatty acids contents, but no significant changes were found in the genes for lipid metabolism. In addition, unlike BPA and BPF exposure, BPS and BPAF exposure also resulted in significant increases in glucose and glycogen contents in the ...Continue Reading

Citations

Dec 28, 2019·International Journal of Environmental Research and Public Health·Jong-Joo KimVijay Kumar
Nov 27, 2019·Scientific Reports·Adebola A Adeyi, Babafemi A Babalola
Sep 1, 2020·Environmental Pollution·Ming-Yu ZhangShun-Feng Cheng
May 14, 2020·The Science of the Total Environment·Young-Ah AhnSungkyoon Kim
Oct 9, 2021·Environmental Toxicology and Pharmacology·Haiyan AnJinshao Ye
Nov 28, 2021·Environmental Science and Pollution Research International·Peng TangXiaoqiang Qiu

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