Effects of perinatal exposure to delta 9-tetrahydrocannabinol on the fetal and early postnatal development of tyrosine hydroxylase-containing neurons in rat brain

Journal of Molecular Neuroscience : MN
A BonninJ J Fernández-Ruiz

Abstract

The exposure of pregnant rats to delta 9-tetrahydrocannabinol (delta 9-THC), the main psychoactive constituent of Cannabis sativa, during the perinatal period affects the gene expression and the activity of tyrosine hydroxylase (TH) in the brains of their offspring at peripubertal and adult ages. In the present work we explored whether these effects also appear during fetal and early neonatal periods, when TH expression plays an important role in neural development. To this end, the mRNA amounts for TH and the amounts and activity of this enzyme, in addition to catecholamine (CA) contents, were analyzed in the brain of fetuses at different gestational days (GD) and of newborns at two postnatal ages, which had been daily exposed to delta 9-THC or vehicle from d 5 of gestation. Results were as follows. The exposure to delta 9-THC markedly affected the expression of the TH gene in the brain of fetuses at GD 14. Thus, the amounts of its mRNA at this age were higher in delta 9-THC-exposed fetuses than in controls. This corresponded with a marked rise in the amounts of TH protein and in the activity of this enzyme at this age. Normalization was found in these parameters at GD16. However, a marked sexual dimorphism in the response of ...Continue Reading

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Citations

Apr 1, 1997·Journal of Molecular Neuroscience : MN·M L HernándezJ J Fernández-Ruiz
Nov 17, 2004·Neurotoxicity Research·Javier Fernández-RuizJosé A Ramos
Jul 2, 2009·European Archives of Psychiatry and Clinical Neuroscience·Didier Jutras-AswadYasmin L Hurd
Aug 26, 1999·Life Sciences·J J Fernández-RuizJ A Ramos
Jul 9, 2002·Brain Research. Developmental Brain Research·Eva M RomeroM Paz Viveros
Jan 13, 2000·Trends in Neurosciences·J Fernández-RuizJ A Ramos
Jun 28, 2003·Neurotoxicity Research·Tomas PalomoRichard M Kostrzewa
Jun 28, 2003·Neurotoxicity Research·José A RamosJavier Fernández-Ruiz
Jan 27, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Elizabeth E ZumbrunMitzi Nagarkatti
Feb 12, 2004·Journal of Psychopharmacology·Maria C Jockers-ScherüblRainer Hellweg
Apr 5, 2017·Neuropharmacology·Miriam MelisDaniela Parolaro
May 14, 2008·The Australian and New Zealand Journal of Psychiatry·Martin CohenVaughan Carr
Jun 20, 2006·Human Psychopharmacology·Suresh Sundram
Jul 2, 2008·Expert Review of Neurotherapeutics·Kirsten R Müller-Vahl, Hinderk M Emrich
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Patrik RoserWolfram Kawohl
Apr 11, 2014·The European Journal of Neuroscience·Keda C TreeFlorence Cayetanot
Aug 14, 2012·Drug Testing and Analysis·Delphine Psychoyos, K Yaragudri Vinod
Jan 20, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Rebecca PollackMassrour Pourcyrous
Nov 27, 2020·Frontiers in Psychiatry·Francisco NavarreteJorge Manzanares
Feb 11, 2021·Toxins·Zeinab BreijyehLaura Scrano
Sep 30, 2018·Neurotoxicology and Teratology·Laura R StroudMarilyn A Huestis
Apr 30, 2021·Heliyon·Priyanka D PinkyMuralikrishnan Dhanasekaran
Feb 12, 1999·Neurobiology of Disease·E L Gardner, S R Vorel
Jul 13, 2006·Neurotoxicology and Teratology·Diana L Dow-EdwardsL R Stanford
Apr 17, 2008·European Journal of Pharmacology·Viviana TrezzaLouk J M J Vanderschuren

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