PMID: 11915366Mar 28, 2002Paper

Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats

The Journal of Toxicological Sciences
Kaori MiyataMasatoshi Matsuo

Abstract

Flutamide, which has antiandrogenic properties, was administered to pregnant rats, and effects on male offspring were examined. Crj: CD (SD) IGS (SPF) females were administered flutamide (0.15, 0.6, 2.5, 10.0, 100 mg/kg, p.o.) from gestation Day 14 to post parturition Day 3. The number of pups, body weights, clinical features, anogenital distance (AGD), nipple retention, testicular descent, and urogenital malformation in F1 males were examined. Hormone measurement, necropsy and histopathological examination were carried out at post-neonatal Day 4 (PND 4) and PND 60. Sperm analysis was also carried out at PND 60. Decrease in body weight was seen in the 100 mg/kg group and the AGD was decreased at 2.5 mg/kg and above. Retention of nipples, hypospadia, vaginal pouches, penis malformation, unilateral ectopic testis, and decrease of organ weights (prostate, seminal vesicles, levator ani muscle plus bulbocavernosus muscle, testis) were observed at 10 mg/kg and above. Testicular testosterone (T) was increased significantly with 100 mg/kg at PND 4 and tendencies for increase were observed in serum T, LH and FSH at 10 mg/kg and more at the same time point. In contrast, elevated levels of LH and FSH were seen with 100 mg/kg at PND 60. Hi...Continue Reading

References

Jan 1, 1978·Annual Review of Physiology·J D Wilson
Nov 1, 1992·Journal of Reproduction and Fertility·P van der Schoot
Nov 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·O P SharmaL L Ewing
Nov 1, 1996·The Journal of Urology·L SeethalakshmiJ Luber-Narod
Jun 18, 1998·Toxicological Sciences : an Official Journal of the Society of Toxicology·E MylchreestP M Foster
Feb 3, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·J C O'ConnorL G Davis
Aug 13, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·S Z CagenL R Harris
Sep 24, 1999·Neurotoxicology and Teratology·A C MonizM M Bernardi
Oct 28, 1999·Regulatory Toxicology and Pharmacology : RTP·R W TylJ P Van Miller
Oct 28, 1999·Regulatory Toxicology and Pharmacology : RTP·S Z CagenL R Harris
Nov 5, 1999·Nature·K L HowdeshellF S vom Saal
May 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·C J WolfL E Gray
May 12, 2000·Proceedings of the Society for Experimental Biology and Medicine·C Gupta
Jul 26, 2000·Reproductive Toxicology·B A ElswickD B Janszen
Dec 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·L G ParksL E Gray
Dec 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·L E GrayL Parks
Apr 10, 2002·Environmental Health Perspectives·Ronald MelnickMichael Kohn

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Citations

Aug 29, 2003·Molecular and Cellular Endocrinology·Isabelle GoddardMohamed Benahmed
Sep 15, 2004·Environmental Health : a Global Access Science Source·Eduardo Salazar-MartinezMauricio Hernandez-Avila
Sep 29, 2009·Reproductive Biology and Endocrinology : RB&E·Thuy T B VoEui-Bae Jeung
Apr 16, 2009·The Journal of Reproduction and Development·Thuy T B VoEui-Bae Jeung
Jan 5, 2008·Environmental Health Perspectives·Ulla HassAndreas Kortenkamp
May 7, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Johnathan R FurrLeon E Gray
Oct 12, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·L Earl GrayPaul M D Foster
Mar 5, 2008·International Journal of Andrology·S ChristiansenU Hass
Jan 22, 2008·International Journal of Andrology·Si Brask SonneHenrik Leffers
Feb 25, 2005·The Journal of Toxicological Sciences·Kazunori GotoKatsushi Suzuki
Sep 17, 2003·The Journal of Toxicological Sciences·Kaori MiyataMasatoshi Matsuo
Dec 1, 2011·Molecular and Cellular Endocrinology·Helena E Virtanen, Annika Adamsson
Sep 21, 2013·Molecular and Cellular Endocrinology·Elena ZambranoPeter W Nathanielsz
Jul 2, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lefteris C Zacharia
Jan 17, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Leon Earl GrayPhillip C Hartig
Mar 16, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tiina F M MikkiläJorma Paranko
Feb 2, 2018·Biological & Pharmaceutical Bulletin·Yasushi NishiokaTsuyoshi Nakanishi
Jun 27, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Justin M ConleyLeon Earl Gray

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