Effects of perinatal HIV infection and associated risk factors on cognitive development among young children

Pediatrics
Renee SmithWomen and Infants Transmission Study Group

Abstract

We examined the effect of HIV, in combination with other important health and social factors, on the development of cognitive abilities of children perinatally exposed to HIV. Serial cognitive assessments were performed for 117 children who were infected vertically and 422 children who were exposed to but not infected with HIV, in a multicenter, natural history, longitudinal study. Repeated-measures analyses were used to evaluate the neurocognitive development of children between the ages of 3 and 7 years, as measured by the McCarthy Scales of Children's Abilities (MSCA). Children with HIV infection and class C status scored significantly lower in all domains of cognitive development, across all time points, than did those who were HIV infected without an AIDS-defining illness and those who were HIV exposed but not infected. There were no significant differences between the 2 latter groups in General Cognitive Index or specific domain scores. Rates of change in cognitive development were comparable (parallel) among all 3 groups over a period of 4 years. Factors that were associated consistently and significantly with lower mean scores were HIV status, number of times an examination had been completed previously, primary languag...Continue Reading

References

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Citations

Aug 21, 2010·Immunologic Research·K Grovit-Ferbas, M E Harris-White
Dec 8, 2009·Journal of Pediatric Psychology·Heather L GambleMary E Randolph
Dec 20, 2011·Journal of Developmental and Behavioral Pediatrics : JDBP·Mabel L RicePaige L Williams
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May 18, 2012·The Pediatric Infectious Disease Journal·Renee SmithUNKNOWN Pediatric HIV/AIDS Cohort Study (PHACS) Team
Sep 5, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Annelies Van RiePaul Stewart
Jul 23, 2009·Annual Review of Medicine·Rohan HazraLynne M Mofenson
Nov 5, 2014·Global Social Welfare : Research, Policy & Practice·Latoya SmallMary McKernan McKay
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Nov 2, 2014·The Pediatric Infectious Disease Journal·Patricia A GarvieUNKNOWN Pediatric HIVAIDS Cohort Study (PHACS)
Dec 8, 2010·Expert Review of Anti-infective Therapy·Caroline Foster, Sarah Fidler
Dec 8, 2015·NeuroImage. Clinical·Benjamin S C WadePaul M Thompson
Mar 1, 2012·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Krista Lee Oswalt, Fred J Biasini
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Jan 10, 2019·Developmental Neuropsychology·Kate Cockcroft, Robyn Milligan
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Jan 4, 2017·The Journal of the Association of Nurses in AIDS Care : JANAC·Kathryn BradyJanice Piatt
Mar 24, 2017·Journal of Tropical Pediatrics·Kenechukwu K IlohAdaeze C Ayuk

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