PMID: 2502707May 1, 1989Paper

Effects of perinatal PCB exposure on discrimination-reversal learning in monkeys

Neurotoxicology and Teratology
S L SchantzN K Laughlin

Abstract

Monkeys exposed to PCB mixtures during gestation and lactation were tested on two-choice discrimination-reversal learning (DR). In Experiment 1, offspring of mothers fed 1.0 ppm Aroclor 1248, and offspring born 1.5 years after maternal exposure to 2.5 ppm Aroclor 1248 ended did not differ from controls on spatial, color or shape DR problems. In Experiment 2, offspring of mothers fed 0.25 or 1.0 ppm Aroclor 1016 and offspring born 3 years after maternal exposure to 2.5 ppm Aroclor 1248 ended were tested on the same spatial, color and shape problems, but a spatial problem with color and shape as irrelevant cues was inserted after the initial spatial problem. Performance of the high dose Aroclor 1016 offspring was impaired on the initial spatial problem, and facilitated on the shape problem. Performance of the Aroclor 1248 postexposure offspring was facilitated on the shape problem. This apparently facilitatory effect may represent a failure of PCB-exposed monkeys to learn the irrelevancy of the shape cue when it was initially presented.

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Citations

Mar 1, 1992·Neurotoxicology and Teratology·E D LevinR E Bowman
Jan 1, 1994·Neurotoxicology and Teratology·B J StruppK Hamberger
Jun 17, 1999·The Science of the Total Environment·K K PflughJ Burger
Sep 7, 2000·Neurotoxicology and Teratology·T M Burbacher, K S Grant
Mar 14, 2003·Neurotoxicology and Teratology·Paul W StewartJames Pagano
May 1, 1996·Neurotoxicology and Teratology·W H HannemanS H Safe
Sep 1, 2002·Environmental Toxicology and Pharmacology·M Christopher Newland
Jan 28, 2004·Neuropsychology·Hestien J I VreugdenhilNynke Weisglas-Kuperus
Jun 16, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Roberta CampagnaRoberta Pastorelli
Sep 11, 2010·Environmental Health Perspectives·Paul A EubigSusan L Schantz
Feb 22, 2008·Environmental Health Perspectives·Kao-Chang LinYueLiang Leon Guo
Dec 1, 1995·Environmental Health Perspectives·D C Rice
Apr 1, 1996·Environmental Health Perspectives·D C RiceC Watanabe
Jan 6, 2010·Environmental Health Perspectives·Deborah C RiceVincent P Markowski
Jun 3, 2014·Neurotoxicology and Teratology·Takayuki NegishiYasuhiro Yoshikawa
Jul 9, 2010·Frontiers in Neuroendocrinology·Prasada Rao S Kodavanti, Margarita C Curras-Collazo
Sep 16, 2011·Journal of Thyroid Research·Marie-Louise Hartoft-NielsenUlla Feldt-Rasmussen
Dec 17, 2010·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Kao-Chang LinDer-Shin Ke
Jun 6, 1998·Experimental Neurology·W D NiemiD O Carpenter
Mar 22, 2015·Behavioural Processes·M Christopher NewlandErin Rasmussen

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