Effects of perindopril on serum lipids in hypertensive patients with hyperlipidemia

Journal of Cardiovascular Pharmacology
M Middeke, W Krone

Abstract

The effect of the angiotensin-converting enzyme (ACE)-inhibitor perindopril on serum lipids and apolipoprotein concentrations were assessed in a multicenter, randomized, double-blind, placebo-controlled study in 51 hyperlipidemic patients treated for mild hypertension. Perindopril was given as a single morning dose (4 mg) for 6 weeks. During the treatment period, blood pressure (BP) was significantly (p < 0.001) reduced from 159/99 to 148/90 mm Hg by verum treatment and from 158/101 to 151/95 mm Hg (NS) by placebo treatment. Neither total cholesterol and triglycerides nor high-density-lipoprotein and apolipoprotein AI and B levels were significantly altered by drug treatment as compared with placebo. Although perindopril had good antihypertensive effect in patients with mild hypertension and hyperlipidemia, it had no adverse effects on lipid metabolism in these patients. Therefore, perindopril is recommended for antihypertensive treatment, especially in hypertensive patients with concomitant hyperlipidemia.

Citations

Dec 25, 2004·International Journal of Clinical Practice. Supplement·I NalbantgilR Onder
Oct 10, 2001·The American Journal of Cardiology·E H Sonnenblick
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Balraj S HeranJames M Wright

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