Effects of Peripheral Immune Challenge on In Vivo Firing of Basolateral Amygdala Neurons in Adult Male Rats

Neuroscience
Soumyabrata Munshi, J Amiel Rosenkranz

Abstract

Peripheral inflammation often causes changes in mood and emergence of depressive behavior, and is characterized by a group of physical manifestations including lethargy, malaise, listlessness, decreased appetite, anhedonia, and fever. These behavioral changes are induced at the molecular level by pro-inflammatory cytokines like interleukin (IL)-1β, IL-6 and TNF-α. The basolateral amygdala (BLA) is a key brain region involved in mood and may mediate some of the behavioral effects of inflammation. However, it is unknown whether peripheral inflammatory state affects the activity of BLA neurons. To test this, adult male Sprague-Dawley rats were treated with IL-1β (1 μg, intraperitoneal (i.p.)), and behavioral and electrophysiological measures were obtained. IL-1β reduced locomotion in the open-field test and also reduced home-cage mobility, consistent with features of sickness-like behavior. Using in vivo single-unit extracellular electrophysiological recordings from anesthetized rats, we found that spontaneous BLA neuronal firing was acutely (<30 min) increased after IL-1β, followed by a return to baseline level, particularly in the basal nucleus of the BLA complex. To verify and expand on effects of peripheral inflammation, we te...Continue Reading

Citations

Aug 28, 2020·Frontiers in Neuroscience·Marissa R KeeverSandra L Rodriguez-Zas
Feb 16, 2021·Neurochemistry International·Katherine PicardMarie-Ève Tremblay
Mar 12, 2021·Biological Psychiatry·Wen-Hua ZhangBing-Xing Pan
May 31, 2021·Brain, Behavior, and Immunity·Karin OdojOlga Garaschuk
Dec 18, 2021·Frontiers in Cellular Neuroscience·Haley A VecchiarelliMatthew N Hill

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