Effects of Peritoneal Sepsis on Rat Central Osmoregulatory Neurons Mediating Thirst and Vasopressin Release

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jerneja StareC W Bourque

Abstract

Sepsis is a life-threatening condition caused by the systemic inflammatory response to a bacterial infection. Although much is known about the cellular and molecular changes that characterize the peripheral inflammatory response to sepsis, almost nothing is known of the neuronal changes that cause associated perturbations in the central control of homeostasis. Osmoregulation is one of the key homeostatic systems perturbed during sepsis. In healthy subjects, systemic hypertonicity normally excites osmoreceptor neurons in the organum vasculosum laminae terminalis (OVLT), which then activates downstream neurons that induce a parallel increase in water intake and arginine vasopressin (AVP) secretion to promote fluid expansion and maintain blood pressure. However, recent studies have shown that the early phase of sepsis is associated with increased AVP levels and suppressed thirst. Here we examined the electrophysiological properties of OVLT neurons and magnocellular neurosecretory cells (MNCs) in acute in vitro preparations obtained from rats subjected to sham surgery or cecal ligation and puncture (CLP). We found that the intrinsic excitability of OVLT neurons was not affected significantly 18-24 h after CLP. However, OVLT neurons...Continue Reading

Citations

May 28, 2016·Clinics in Chest Medicine·Aurelien MazeraudTarek Sharshar
Oct 5, 2016·Aging and Disease·Ting LiRongqiao He
May 8, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Aurélien MazeraudTarek Sharshar
Jun 8, 2017·Pituitary·Nilton Nascimento Santos-JuniorMaria José Alves Rocha
Mar 23, 2017·Critical Care : the Official Journal of the Critical Care Forum·Nicholas HemingTarek Sharshar
May 22, 2017·Current Hypertension Reports·Brian J KinsmanSean D Stocker
Aug 19, 2020·International Journal of Environmental Research and Public Health·Piotr F CzempikŁukasz J Krzych
Mar 3, 2020·Journal of Neuroimmunology·Rafael Alves CazuzaChristie Ramos Andrade Leite-Panissi
Jul 17, 2021·Frontiers in Veterinary Science·Bernie Hansen

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